Dipyrone (INN, metamizol) is a common analgesic used worldwide. Its widespread prescription or over-the-counter use in many countries (e.g., Brazil, Israel, Mexico, Russia, Spain) requires insight into its mode of action. This study therefore addressed the impact of its metabolites 4-methyl-amino-antipyrine (MAA) and 4-amino-antipyrine (AA) on peripheral cyclooxygenases (COX). Pharmacokinetics ...

The objective of this study was to compare 3 total intravenous anesthetic infusion combinations in adult horses for cardiopulmonary changes, muscle relaxation, duration of recumbency, and quality of recovery. This was a prospective, randomized, crossover, experimental study. Six healthy, adult, mixed-breed horses weighing 460 ± 30 kg were used. The 3 total intravenous anesthetic combinations us...

background: atrazine is a widely used herbicide. the increasing salinity of many water resources has had a negative effect on atrazine biodegradation. the aim of this study was to isolate atrazine degrading bacteria in semi-salinity media.   methods: nine selected bacterial species were cultivated on the mineral salt broth culture medium containing atrazine (50, 100, 500 mg/l), nacl concentrati...

We tend to perceive and emphasize the transition from Late Antiquity Early Middle Ages, especially in North Africa, through ruptures changes. This collection of papers highlights, alongside major changes transformations that affected entire Mediterranean region, longer-term processes developments Africa between AD 500 1000. In this time frame, region is shaped by Vandal, Byzantine Arab conquest...

Abstract On base of the content Pb in soil under different land use patterns Lanping Lead-zinc mining area, Yunnan southwest China, root morphology and leaf traits maize concentration (20, 40, 60, 80, 100, 150, 200, 500, 1000, 2000, 3000 mg/L) were analyzed. The results showed that germination rate, vigor growth index decreased with increase concentration. length, surface area increased by 0.21...

BACKGROUND AND OBJECTIVES Dalbavancin is a novel, once-weekly glycopeptide antibiotic approved for treatment of acute bacterial skin infections. Given the importance of understanding any pharmacokinetic variability across different patient populations, a double-blind, placebo-controlled study was conducted to evaluate the pharmacokinetics, safety, and tolerability of a single 500-mg and a singl...