TWIST1, a transcription factor, plays a pivotal role in cancer initiation and progression. Anaplastic thyroid carcinoma (ATC) is one of the deadliest human malignancies; TWIST1 is overexpressed in ATC and increases thyroid cancer cell survival, migration and invasion. The molecular mechanisms underlying the effects of TWIST1 are partially known. Here, using miRNome profiling of papillary thyroi...

ENWEndNote BIBJabRef, Mendeley RISPapers, Reference Manager, RefWorks, Zotero AMA JAFARI H, Heidari M, Sadeghi R, HEIDARI-JAMEBOZORGI M. Factors affecting the resilience of hospital medical staff during COVID-19 pandemic. Family Medicine & Primary Care Review. 2023;25(1):50-54. doi:10.5114/fmpcr.2023.125492. APA JAFARI, H., Heidari, M., Sadeghi, R., HEIDARI-JAMEBOZORGI, (2023). Review, 25(1), 5...

Introduction . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 584 Step 1: developing the study question . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 584 Defining the study question . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . ...

Over the years, several researchers have worked to model phenomena in which distribution of data presents more or less heavy tails. With this aim, generalizations extensions Lomax been proposed. In paper, an attempt is made create a hybrid mixing functionalities Nadarajah–Haghighi and distributions, namely (NHLx) distribution. It can also be thought as extension exponential The NHLx has feature...

9-([2-Methoxy-4-[(methylsulfonyl)amino]phenyl]amino)-N,5-dimethyl-4- acridinecarboxamide (CI-921), an analogue of the clinical antileukemia drug amsacrine with improved solid tumor activity in mice, is currently being evaluated in patients. In order to determine whether CI-921 possesses any advantages over amsacrine in terms of tissue delivery, the pharmacokinetics of amsacrine and CI-921 were ...

BACKGROUND Uncovering the target gene of miR-584 to control thyroid carcinoma (TC) invasion and migration is of central importance in the diagnosis, treatment, and prognosis of TC. To validate whether miR-584 has a tumor-suppressive role in thyroid cancer cells by targeting ROCK1, a series of experiments were conducted to figure out the mechanism of action of miR-584. MATERIAL AND METHODS Mig...

In traditional approaches business processes are executed on top of IT-based Workflow-Management Systems (WfMSs). However, when dealing with human-driven workflows, conventional WfMSs may turn out to be too restrictive. Especially, the only way to handle exceptions is to bypass the system. If users are forced to bypass WfMSs frequently, the system is more an obstacle than an asset. In order to ...

Upon fusion of the secretory granule with the plasma membrane, lumenal constituents are discharged at very different rates. This is explained in some cases by molecular size. For example, a low molecular weight neurotransmitter such as epinephrine is usually discharged in fewer than 100 ms, whereas co-stored proteins can be released over many seconds. Specific proteins can be discharged at wide...

When Laveran (1) discovered living malarial parasites over 65 years ago in the blood of patients with certain fevers, a new era in the study of malaria was initiated. This discovery of malarial organisms and the subsequent experimental proof by a series of workers that they were the etiological agents of the disease failed, however, to lead to the immediate successful cultivation of the parasit...