the crankshaft is one of the most critically loaded components as it experiences cyclic loads in the form of bending and torsion during its service life. its failure will cause serious damage to the engine so it’s important at the time of design to verify fatigue strength. more challenges in crankshaft design due to increasing vehicle payloads, lower weight requirement, higher efficiency and lo...

Analysis of accumulation of repair and checkpoint proteins at repair sites in yeast nuclei has conventionally used chemical agents, ionizing radiation or induction of endonucleases to inflict localized damage. In addition to these methods, similar studies in mammalian cells have used laser irradiation, which has the advantage that damage is inflicted at a specific nuclear region and at a precis...

Microdamage accumulates in bone due to repetitive or excessive mechanical loading, and accumulation of damage can lead to an increase in fracture susceptibility. Understanding the stress or strain criterion for damage formation would allow improved predictive modeling to better assess experimental results or evaluate training regimens. Finite element models coupled with three-dimensional measur...

The crankshaft is one of the most critically loaded components as it experiences cyclic loads in the form of bending and torsion during its service life. Its failure will cause serious damage to the engine so it’s important at the time of design to verify fatigue strength. More challenges in crankshaft design due to increasing vehicle payloads, lower weight requirement, higher efficiency and lo...

We developed a model, termed D-PSA-K, to estimate the accumulated potential damage on kiwifruit canes caused by bacterial canker during the growing and overwintering seasons. The model consisted of three parts including estimation of the amount of necrotic lesion in a non-frozen environment, the rate of necrosis increase in a freezing environment during the overwintering season, and the amount ...

A probabilistic method to predict macrocrack initiation due to fatigue damage is presented in this paper. Acoustic non-linearity is used to quantify pre-macrocrack initiation damage. This data is then used in a probabilistic analysis of fatigue damage. The probabilistic fatigue damage analysis consists of a suitably chosen damage evolution equation to model accumulated damage coupled with a pro...

Recovery from DNA damage is critical for cell survival. The serious damage is not able to be repaired during checkpoint and finally induces cell death to prevent abnormal cell growth. In this study, we demonstrated that 8N-DNA contents are accumulated via re-replication during prolonged recovery period containing serious DNA damage in mitotic cells. During the incubation for recovery, a mitotic...