Introduction: Psychotropic drugs exert their effects, in part, by increasing neurotrophin levels in the brain. Nerve growth factor (NGF) protein levels after treatment with only a limited number of psychotropics have been determined. The present study was designed in order to evaluate the effects of acute and chronic administration of different psychotropic drugs on NGF protein levels in fiv...

Objective(s) Psychotropic medications produce their effects, in part, through increasing neurotrophin levels in the brain. Since studies concerning nerve growth factor (NGF) analysis have been limited in scope, in the current experiments we investigated the effects of diverse psychotropic agents on NGF protein levels in various brain regions of rat. Materials and Methods Male Wistar rats rec...

Introduction: Some studies indicate changes in the level of thyroid hormones in addicted people. Also, there are some reports concerning the modulation of hypothalamus-hypophysis-thyroid axis in the context of morphine addiction. In the present study, the effects of thyroid gland activation via the acute and chronic administration of levothyroxine on morphine withdrawal syndrome were investi...

increased arginase activity in the airways decreases l-arginine and causes deficiency of bronchodilating and anti-inflammatory nitric oxide (no) in asthma. as, it is suggested that l-arginine may have therapeutic potential in asthma treatment, we aimed to investigate the effects of inhaled l-arginine on oxygen saturation (sao₂) and airway histology in a murine model of acute asthma. twenty eigh...

tramadol hydrochloride, a synthetic opioid, acts via a multiple mechanism of action. tramadol can potentially change the behavioral phenomena. the present study evaluates the effect of tramadol after single or multiple dose/s on the spatial memory of rat using object recognition task (ort). tramadol, 20 mg/kg, was injected intraperitoneally (i.p) as a single dose or once a day for 21 successive...