administration of apomorphine and amphetamine induces climbing behavior in mice due to stimulation of brain dopamine receptors. in the present study, the effects of adrenoceptor agonists and antagonists on amphetamine-induced climbing have been investigated. intraperitoneal (i.p.) injection of different doses of amphetamine (2,4 and 8 mglkg) induced climbing in mice (p

Cancer is one of the leading causes death in world. Researchers keep attempting to develop therapy modalities decrease mortality and morbidity cancer patients by trying comprehend effect sympathetic nerves (through catecholamine adrenergic receptors) development. Catecholamine activation β-adrenergic receptors (β1-AR, β2-AR, β3-AR) may influence cytokine immunity system, initiate tumorigenesis,...

cirrhosis is characterized by marked abnormalities in the cardiovascular system. a hyperdynamic splanchnic and systemic circulation is typical of cirrhotic patients and has been observed in all experimental forms of portal hypertension. the hyperdynamic circulation is most likely initiated by arterial vasodilatation, leading to central hypovolemia, sodium retention, and an increased intravascul...

Neuropeptide Y and Sympathetic Nervous System in Blood Pressure Regulation To the Editor: We read with great interest the recent article by Dr Michalkiewicz and his colleagues1 dealing with a possible link between neuropeptide Y (NPY) and sympathetic nervous system in the NPY-transgenic rats. The results of their presented study demonstrated that overexpression of endogenous NPY in the transgen...

Different beta 1 and 2 adrenergic receptors agonists might have various biological and physiological effects on fish species. An experiment was designed to study the effects of feeding ractopamine, terbutaline and metaproterenol; as beta1, beta2 and less selective beta2 adrenergic receptor agonists, respectively; on body weight gain, feed conversion rate, concentration of biochemical parameters...

At present, there is no treatment option available for COVID-19 condition and most importantly the underlying pathophysiology in not known. In this article, I had given a viewpoint that explains based on it proposed options COVID-19. propose adrenergic storm-induced Warburg effect (aerobic glycolysis) may be mechanism condition. alpha1 blockers early phase beta-adrenergic late of to inhibit sto...

The adenylate cyclase-coupled &-adrenergic receptor of the frog erythrocyte has served as a useful model system for elucidating the mechanisms of catecholamine-induced desensitization. In this system, it has been previously demonstrated that agonist-induced refractoriness is associated with sequestration of the @adrenergic receptors in vesicles away from the cell surface and from their effector...