chronic exposure to lead (pb) affects neural functions in central nervous system (cns) particularly the learning and memory. on the other hand, alteration of calcium level in the cns results in activation of nos. it has been shown that lead enters the neurons through calcium channels and displaces ca2+ from calcium binding proteins such as calmodulin and troponin c thereby affecting calcium-med...

background: release of vascular endothelial growth factor (vegf) by ovaries in response to hcg administration is one of the main mechanisms of ovarian hyper stimulation syndrome. since dopamine/dopamine receptor2 (dp-r2) pathway activity -mediated by vegf/ vascular endothelial growth factor receptor 2 (vegfr-2) signaling-, is associated with angiogenic events, dopamine agonists were used for th...

cannabinoids induce diverse responses on anxiolytic–like behaviors. moreover some studies postulated that there is a close relationship between this system and serotonergic system upon cognitive process formation. thus the aim of present study is investigation the possible role of 5-ht 1 receptor on anxiolytic–like behaviors induced by acpa in the elevated plus maze task (epm). in the present s...

abstract the gnrh analogue (agonist and antagonist gnrh) changed ovarian stimulation. on the one hand, it improved chances of pregnancy to obtain more oocytes and better embryos. this leads to an ovarian hyper-response, which can be complicated by the ovarian hyperstimulation syndrome (ohss). on the other hand, the gnrh analogue can prevent the incidence of ohss: gnrh antagonist protocols, gnrh...

background: gnrh agonist and antagonist were developed to control the premature release of lh surge. there is some difference between two protocols. objective: we compared the outcome of frozen-thawed embryo transfer in infertile women who used gnrh agonist or antagonist protocol for previous coh cycle and evaluation of any adverse effect of gnrh antagonist on oocyte and embryo. materials and m...

Background To compare a flexible, multi-dose GnRH antagonist protocol with a long GnRH .agonist protocol in poor respo MaterialsAndMethods A randomized clinical trial of 70 poor responder patients (35 patients in GnRH antagonist protocol and 35 patients in long GnRH agonist protocol) was performed at Royan Institute, Tehran, Iran. Both groups were given a fixed dose of human menopausal gonadotr...