The present investigation is primarily concerned with the isolation of p-aminobenzoic acid from yeast. The presence of this substance in yeast was adumbrated by Woods (1) who made the important discovery that. this aromatic amino acid possesses the unique propcity of antagonizing the bsctcriostat~ic action of sulfanilamidt? and that the component. of yeast extracts which exerts a similar antisu...

The bacteriostatic action of 2-chloro-4-aminobenzoic acid (2-Cl-PAB) was found by Wyss, Rubin, and Strandskov (1943) to be completely reversed by p-aminobenzoic acid. This, according to the theory of Woods (1940) that p-aminobenzoic acid is a specific antagonist for sulfanilamide, classified the bacteriostatic action of 2-Cl-PAB as sulfonamide activity. The bacteriostatic action of this compoun...

The mechanism whereby sulfanilamide and its derivatives prevent bacterial growth is not known. None of the various theories advanced (1-3) has been conclusively substantiated by direct experimental proof. The most important recent contribution to the problem has been that of Woods (4), who demonstrated that p-aminobenzoic acid "blocks" the bacteriostatic effect of sulfanilamide in vitro. Follow...

objective(s):involvement of tyrosinase in the synthesis of melanin and cell signaling pathway has made it an attractive target in the search for therapeutic inhibitors for treatment of different skin hyperpigmentation disorders and melanoma cancers. materials and methods: in the present study, we conducted a comprehensive kinetic analysis to understand the mechanisms of inhibition imposed by 2-...

Microorganisms that require p-aminobenzoic acid or compounds of the folic acid group may have either requirement replaced by a purine and thymine (or thymidine) and several amino acids or vitamin B12 (Lampen et al., 1949; Stokstad, 1941; Baker et al., 1955); the vitamins, p-aminobenzoic or folic acids, are believed necessary for the synthesis of those compounds which can bypass them (Shive, 195...

Objective(s):Involvement of tyrosinase in the synthesis of melanin and cell signaling pathway has made it an attractive target in the search for therapeutic inhibitors for treatment of different skin hyperpigmentation disorders and melanoma cancers. Materials and Methods: In the present study, we conducted a comprehensive kinetic analysis to understand the mechanisms of inhibition imposed by 2-...