We describe a new proof of the complete integrability of the two related dynamical systems: the billiard inside the ellipsoid and the geodesic flow on the ellipsoid (in Euclidean, spherical or hyperbolic space). The proof is based on the construction of a metric on the ellipsoid whose nonparameterized geodesics coincide with those of the standard metric. This new metric is induced by the hyperb...

Evidence-based medicine has been defined as the conscientious and judicious use of current best evidence in making clinical decisions. This paper will attempt to explicate the terms “conscientious” and “judicious” within the evidence-based medicine definition. It will be argued that “conscientious” and “judicious” represent virtue terms derived from virtue ethics and virtue epistemology. The id...

...............................................................................................................v 1 The Problem of Understanding Program Behavior....................................1 2 Background: Function-Theoretic Foundations of FSQ Flow Structures..3 3 Function-Theoretic Calculation of Program Behavior ...............................6 4 The Architecture of an Abstraction Engin...

We read with great interest the Highlight Review by Dr C GruÈ ndker entitled `Cytotoxic luteinizing hormonereleasing hormone conjugates and their use in gynecological cancer therapy' in the European Journal of Endocrinology (1). This excellent article provides a detailed description of recent developments in the field of targeted chemotherapy based on luteinizing hormone-releasing hormone (LH-R...

Recently, we developed a series of cytotoxic peptide conjugates containing 14-O-glutaryl esters of doxorubicin (DOX) or 2-pyrrolino-DOX (AN-201). Serum carboxylesterase enzymes (CE) can partially hydrolyze these conjugates in the circulation, releasing the cytotoxic radical, before the targeting is complete. CE activity in serum of nude mice is about 10 times higher than in human serum. Thus, w...