A distinctive feature of the voltage-dependent chloride channels ClC-0 (the Torpedo electroplaque chloride channel) and ClC-1 (the major skeletal muscle chloride channel) is that chloride acts as a ligand to its own channel, regulating channel opening and so controlling the permeation of its own species. We have now studied the permeation of a number of foreign anions through ClC-1 using voltag...

Single channel currents though apical membrane Cl channels of the secretory epithelial cell line T84 were measured to determine the anionic selectivity and concentration dependence of permeation. The current-voltage relation was rectified with single channel conductance increasing at positive potentials. At 0 mV the single channel conductance was 41 +/- 2 pS. Permeability, determined from rever...

The study was conducted to evaluate the hydrogeochemistry of groundwater. Twenty-six groundwater samples were analysed for quality Chachro Taluka. EC and TDS contents in most water above WHO (2011) recommended limits. Almost all collected from dugwells located area have elevated concentrations Na Cl exceeding guidelines. Results Ca, Mg show that 92% 96% within prescribed limit respectively. Whe...

Hydrochemical assessment of the freshwater lakes provides important insights into sources dissolved ions, geochemical processes, and anthropogenic activities taking place in environment. This study focuses on hydrochemistry water quality Kupinde Lake, Karnali Province, Nepal. Surface samples were collected from 24 different locations lake October 2021 analyzed for 18 physico-chemical parameters...

The nature of the intracellular pH-regulatory mechanism after imposition of an alkaline load was investigated in isolated human peripheral blood neutrophils. Cells were alkalinized by removal of a DMO prepulse. The major part of the recovery could be ascribed to a Cl-/HCO3- counter-transport system: specifically, a one-for-one exchange of external Cl- for internal HCO3-. This exchange mechanism...