In the pediatric cancer neuroblastoma, clinically aggressive disease is associated with increased levels of angiogenesis stimulators and high vascular index. We and others have hypothesized that blocking angiogenesis may be effective treatment for this pediatric malignancy. However, little is known about the efficacy of antiangiogenic agents in pediatric malignancies. Recently, promising result...

Arsenic is a wide spread carcinogen associated with several kinds of cancers including skin, lung, bladder, and liver cancers. Lung is one of the major targets of arsenic exposure. Angiogenesis is the pivotal process during carcinogenesis and chronic pulmonary diseases, but the role and mechanism of arsenic in regulating angiogenesis remain to be elucidated. In this study we show that short tim...

Cancer is a consequence of uncontrolled cell proliferation that associated with cell-cycle disruption. It multifactorial disease depends on the modulation numerous oncogenic signaling pathways and targets. Although battle against cancer has been waged for centuries, this remains major cause death worldwide. Because development resistance to current anticancer drugs, substantial effort focused d...

how the seeds of delphinium staphisagria promote hair growth in humans is yet to be discovered. this lack of information leads us to the investigation of hair promoting effects of seeds of delphinium staphisagria in vitro. extract prepared from the seed of delphinium staphisagria (esds) - traditionally used for hair loss treatment - was selected and tested for the cytotoxic and angiogenic poten...

Objective: The equilibrium of angiogenesis stimulus agents and angiogenesis inhibitory agents is an important factor in the increase of diabetic cardiomyopathy. This research aimed to survey the result of eight weeks of high-intensity interval training (HIIT) and moderate continuous (MICT) on the myocardium angiogenesis agent and histological alterations within male diabetic rats. Materials an...

Introduction: Angiogenesis, the process of new blood vessel formation from pre-existing vessels, has important physiological roles in embryonic development, female reproduction cycle, and wound healing. It is also crucial for pathological processes in several diseases especially tumor growth and metastasis. Thereby, inhibition of angiogenesis as an addition to the conventional therapies such...

To characterize concentrated growth factors (CGFs) in vivo, we examined the degradation of implanted CGF rabbits. Untreated (U-CGF) and compressed (C-CGF) were subcutaneously into dorsum. Histological analyses showed that U-CGF C-CGF induced very few inflammatory cells subsequently degraded with dendritic invasion granulation tissue. The histopathologically remained for longer term than U-CGF. ...

BACKGROUND Angiogenesis, the formation of new blood vessels, is an integral part of both normal developmental processes and numerous pathologies, ranging from tumor growth and metastasis to inflammation and ocular disease. Angiogenesis assays are used to test efficacy of both pro- and antiangiogenic agents. METHODS Most studies of angiogenesis inducers and inhibitors rely on various models, b...

Background: It seems that Vinca. herbacea has an anti-tumor effect. Here, the immunotherapeutic effect of this compound is assessed against human ovarian cancer (SKOV3) cells because of the high incidence of this tumor in women. Materials and Methods: The cytotoxic activity of V. herbacea extract against human ovarian cancer (SKOV3) cells was determined by MTT assay. The apoptosis-inducing pote...