Nonsteroidal anti-inflamatory drugs (NSAIDs) and glucocorticoids, nowaday are the main groups of anti-inflamatory drugs in modern pharmacology. The side effects of these antiinflamatory drugs, specially using in chronic diseases cause many problems for the patients and the physicians, so finding the new anti-inflamatory drugs with less side effect is the aim of many researchers. WHO emphasiz to...

Nonsteroidal anti-inflamatory drugs (NSAIDs) and glucocorticoids, nowaday are the main groups of anti-inflamatory drugs in modern pharmacology. The side effects of these antiinflamatory drugs, specially using in chronic diseases cause many problems for the patients and the physicians, so finding the new anti-inflamatory drugs with less side effect is the aim of many researchers. WHO emphasiz to...

It is estimated that 80% of people in developing countries are completely dependent on traditional and folk medicines for their health care. The contribution of medicinal plants and natural products as drugs or as sources of useful drugs in medicine is unquestionable. There are many reports of medicinal plants capable of interfering with the pathophysiological processes in inflammation. Plant e...

a series of five-membered heterocyclic rings were synthesized by the reaction between benzoyl chloride and various chlolro-nitro-benzoyl chlorides and semi carbazide to form (c1-c7) compounds and was tested for their anti-inflammatory activity determined by rat-paw-oedema method. all the synthesis compounds have been characterized by 1hnmr, ir and mass spectral data. the compounds were purified...

the novel bicyclo thieno 1, 2, 3-triazines (btt) namely btt-1, btt-2, btt-3 and btt-4 were evaluated for analgesic anti-inflammatory and antiarthritic activity. analgesic and anti-inflammatory activity was evaluated using hot plate test , formalin induced paw licking test and formalin induced paw edema test respectively, complete fruend’s adjuvant (cfa) induced arthritis model was used for anti...

Tooth pulpal nerves include sympathetic and sensory nerves that originate from trigeminal ganglion .From the terminal of these sensory nerves neuropeptides are secreted that are neuromodulators and neurotransmitters. One of them is CGRP (Calcitonin gene-related protein) which has a vasodilatory effect on pulpal vessels. Near abscess and moderate injuries, this neuropeptide can lead to neural fi...

The computer analysis of relations between molecular structures and their biological activity using fragmentbased methods is very useful to draw conclusions for the understanding of drug action and for the development of more efficient non-toxic drug candidates. We used the computer system SARD-21 (Structure Activity Relationship & Design) to investigate common structural features (fragments an...

Nervous and immune system interact through many different messenger substances such as neurotransmitters, cytokines or neuropeptides. For instance, neuropeptides are capable of affecting the metabolism of cells belonging to the immune system. Conversely, cytokines such as tumor necrosis factor (TNF)-alpha, interferon (IFN)-alpha and IFN-gamma, contribute to the receptor resistance of neuropepti...