In respect to the functional activities of D-cycloserine scientists suggested anticonvulsive activities [4,5] and furthermore the application seems to improve memory and cognitive function. Recently we discovered that D-Cycloserine has the ability to block kynurenic acid synthesis [6]. Kynurenic acid, a metabolite along the kynurenine pathway of tryptophan degradation blocks the glycine sites o...

Long QT syndrome is a cardiac repolarization disorder and is associated with an increased risk of torsades de pointes. The acquired form is most often attributable to administration of specific medications and/or electrolyte imbalance. This review provides insights into the risk for QT prolongation associated with drugs frequently used in the treatment of chronic pain. In the field of pain medi...

Introduction: Some studies show magnesium has anticonvulsive effect in some animal models. Despite of the availability of well-studied anticonvulsant drugs, this evaluation was not carried on new kind of magnesium supplement, magnesium oxide nanoparticles (nMgO). According to the interaction between magnesium and convulsion, this study was designed to evaluate the effect of nMgO on strychnine-i...

Valerenic acid (VA)-a β2/3-selective GABA type A (GABAA) receptor modulator-displays anxiolytic and anticonvulsive effects in mice devoid of sedation, making VA an interesting drug candidate. Here we analyzed β-subunit-dependent enhancement of GABA-induced chloride currents (IGABA) by a library of VA derivatives and studied their effects on pentylenetetrazole (PTZ)-induced seizure threshold and...

PURPOSE Low-frequency ultrasound has a significant effect on the transdermal permeation of high molecular weight drugs. However, the rate of permeation in pulsed mode is quite low necessitating considerable time to apply the ultrasound. 0.5 MHz ultrasound, which is a relatively higher frequency in the low-frequency range, can be applied in high intensity in continuous mode. METHODS A transduc...

introduction: some studies show magnesium has anticonvulsive effect in some animal models. despite of the availability of well-studied anticonvulsant drugs, this evaluation was not carried on new kind of magnesium supplement, magnesium oxide nanoparticles (nmgo). according to the interaction between magnesium and convulsion, this study was designed to evaluate the effect of nmgo on strychnine-i...

Nonopioid analgesics such as acetaminophen can be used as adjuncts. EUROPATHIC PAIN SYNDROMES are challenging to treat. New drugs aim at the mechanisms of the pain, but results are still less than desirable. Newer antidepressants and anticonvulsive drugs are becoming first-line treatments in many patients. And we now know that, contrary to conventional wisdom, opioids do have a role in treating...

INTRODUCTION Some studies showed that magnesium has anticonvulsive effect in some animal models. Despite of the availability of well-studied anticonvulsant drugs, this evaluation was not carried on new kind of magnesium supplement, magnesium oxide nanoparticles (nMgO). According to the association between magnesium and convulsion and high prevalence of seizure and epilepsy in diabetics, this st...