Ultraviolet radiation (UVR) is generally considered a primary tumorigenic agent. While UVR exposure has been studied, especially at the skin level, impact of UV on internal tissues and its effect appearance development tumors not yet fully examined. Although there are maximum limits for external tissues, other such as oral tissue, can be exposed to well. Over course diagnosis treatment, cells m...

Objective(s): The aim of this study was to determine the important molecules involved in apoptosis induction by opium in Jurkat cell line. Materials and Methods: Jurkat cells were incubated 48 hrs with2.86×10-5 g/ml concentration of opium and apoptosis as well as expression levels of related molecules weremeasured. Results: Our results demonstrated that 50.3±0.2 percent of opium treated Jurka...

Abstract A poptosis r elated protein in T GF-? s ignaling pathway (ARTS) was originally discovered cells undergoing apoptosis response to TGF-?, but ARTS also acts downstream of many other apoptotic stimuli. induces by antagonizing the anti-apoptotic proteins XIAP and Bcl-2. Here we identified pro-apoptotic Sept4/ARTS gene as a p53-responsive target gene. Ectopic p53 variety p53-inducing agents...

calprotectin, a calcium-bound protein complex, is abundant in the cytosol of neutrophils. it has been reported that this protein has an apoptotic activity in tumor cells. since calprotectin increases in colorectal cancer, this study was conducted to investigate, for the first time, the cytotoxicity/apoptotic effect of calprotectin on ht29/219 and sw742 colon carcinoma and adenocarcinoma cell li...

In this study, colchicine's cytotoxic effects on SNU-1 cells were examined, and a probable mechanism behind its cytotoxicity was revealed. According to the results of colchicine displayed considerable with an IC50 value 14.81ng/ml when it administered for 24 hours at different doses ranging from 5 100ng/ml. Furthermore, according mechanistic studies, usege significantly increased both early lat...