Background and Aims: Detection of overexpression in tumor-inhibiting genes provides valuable information for leukemia diagnosis and prognosis. Chronic myeloid leukemia (CML) is a stem cell disorder determined by a well-defined genetic anomaly involving BCR-ABL translocation in the Philadelphia chromosome. Curcumin is a chemo-preventive agent for the primary cancer targets, such as the breast, p...

Paradoxically, many microRNAs appear to exhibit entirely opposite functions when placed in different contexts. For example, miR-125b has been shown be pro-apoptotic some studies, but anti-apoptotic others. To investigate this phenomenon, we combine computational modeling with experimental approaches examine how the function of apoptosis varies respect expression levels its and targets. In so do...

Background: Hepatocellular carcinoma (HCC), primary liver cancer, is a major health problem and the third most common cause of cancer-related deaths worldwide. Epigenetic modulations are essential for the maintenance of gene expression patterns in mammals. Disruption of these processes can lead to silenced gene and malignant cellular transformation. The current study was designed to compare the...

apoptosis or programmed cell death is a gene regulated phenomenon which is important in both physiological and pathological conditions. it is characterized by distinct morphological features including chromatin condensation, cell and nuclear shrinkage, membrane blebbing and oligonucleosomal dna fragmentation. although, two major apoptotic pathways including 1) the death receptor (extrinsic) and...

Abstract FK506-binding protein 2 (FKBP13) is a part of the immunophilin family involved in immunoregulation. It also believed to operate as factor membrane cytoskeletal framework and an ER chaperone. FKBP2 FKBP1 (FKBP12), known immunophilins, are binding proteins for rapamycin FK506, which immunosuppressive drugs. was suggested that immunophilin-like play significant roles regulating intracellu...

objective: curcumin, is the active component in turmeric (curcuma long). this agent induces apoptosis via inhibiting various signaling pathways. however, its poor aqueous solubility prevents its widespread application. in this study, dendrosomes with water-solubility, nano-sized dimensions and nontoxic properties, was used for curcumin delivery to cells. materials & methods: in the present...

Betulinic acid, BA, is a lupane derivative that has caught the interest of researchers due to wide variety pharmacological properties it exhibits towards tumor cells. Because their prospective increased anti−proliferative efficacy and improved profile, BA derivatives continue be described in scientific literature. The current work was conducted order determine antiproliferative activity, under ...

BACKGROUND: Doxorubicin (DOX) is a drug that frequently used to treat variety of cancers. Unfortunately, in many situations, it ineffective, and raising the dosage restricted due systemic toxicity. An important strategy minimize toxic effects above cited use co-adjuvant. A citrus flavonoid hesperidin (Hesp) has emerged as promising anticancer natural product proved be potent antioxidant agent. ...