mdma generally known as ecstasy, have deleterious effects on the serotonergic neurotransmitter system. recent findings suggest that the liver and brain are major target organs of mdma-related toxicities. although most research is being dynamically performed on brain, however, the molecular mechanisms by which mdma elicits adverse effects in both organs are poorly undrestood.the present study wa...

background 3-4methylenedioxymethamphetamine (mdma) is a synthetic and psychoactive drug, which is known popularly as ecstasy and has toxic effects on human organs. objectives considering the potential toxic interaction, this study was performed to quantify the expression of bax and bcl2 genes in mdma-induced hepatotoxicity on rat liver. subsequently, we evaluated pentoxifylline as a possible pr...

background and aims:in neurodegenerative disorders,oxidative stress mediated by reactive oxygen species is strongly associated with increased neuronal damages which can lead to apoptosis. pro-apoptotic and anti-apoptotic gene expressions are changed during the cell differentiation that affect cell viability and differentiation. therefore, this study was conducted to determine the effects of hyd...

Background and Objective: In neurodegenerative disorders, oxidative stress mediated by reactive oxygen species is strongly associated with increased neuronal damages that lead to apoptosis. Pro-apoptotic and anti-apoptotic gene expressions were changed during cell differentiation that affect cell viability and differentiation. This study was conducted to determine the effects of hydrogen peroxi...

Background and Aims:In neurodegenerative disorders,oxidative stress mediated by reactive oxygen species is strongly associated with increased neuronal damages which can lead to apoptosis. Pro-apoptotic and anti-apoptotic gene expressions are changed during the cell differentiation that affect cell viability and differentiation. Therefore, this study was conducted to determine the effects of hyd...

background and objective: in neurodegenerative disorders, oxidative stress mediated by reactive oxygen species is strongly associated with increased neuronal damages that lead to apoptosis. pro-apoptotic and anti-apoptotic gene expressions were changed during cell differentiation that affect cell viability and differentiation. this study was conducted to determine the effects of hydrogen peroxi...

Abstract A poptosis r elated protein in T GF-? s ignaling pathway (ARTS) was originally discovered cells undergoing apoptosis response to TGF-?, but ARTS also acts downstream of many other apoptotic stimuli. induces by antagonizing the anti-apoptotic proteins XIAP and Bcl-2. Here we identified pro-apoptotic Sept4/ARTS gene as a p53-responsive target gene. Ectopic p53 variety p53-inducing agents...

Background: Vitrification of oocytes is a fast-freezing technique, which may affect the quality of the human oocyte, and consequently affects the embryo development, pregnancy and birth. The aim of the current study was to investigate the consequence of in-vitro vitrification on maturation status of immature human oocytes, additionally, expression levels of stress, and apoptosis related genes. ...