In this study, l-131-MIBG imaging was performed in 44 patients with clinical suspicion of tumors originating from neuro-endocrine system. The patients were referred to our department following plasma and urinary measurement of epinephrine, norepinehrine and vanilmandelic acidfVMA). Radionuclide imaging was performel as a comparative or confirmatory measure in all patients who had previous...

Liver Transplantation for Malignant Disease" Results in 93 consecutive patients. Ninety-three patients with malignant disease underwent orthotopic liver transplantation between May 1968 and April 1987 in the Cambridge/King's Hospital program. Of 50 patients with primary hepatocellular carcinoma (HCC) (19 with cirrhosis, 31 without cirrhosis, including 7 with fibrolamellar variant), 37 (74%) sur...

A mouse monoclonal antibody, FKH1, was produced to detect cytoplasmic melanoma-associated antigen. FKH1 was raised using cultured human melanoma cell line KHm-6 as an immunogen. Reactivity of this antibody was assessed by immunohistochemical techniques against cell lines and normal and neoplastic tissues. Positive reactions were seen against 5 human melanoma cell lines. It stained cytoplasm of ...

Two human colon carcinoma cell lines derived from the same tumor specimen were characterized. The cell lines, COLO 320 and COLO 321, have amine precursor uptake and decarboxylation cell properties, such as ectopic production of norepinephrine, epinephrine, serotonin, adrenocorticotropic hormone, and parathyroid hormone. The cells were morphologically different from most colon cell lines. Double...

Anatomo-clinical studies of the neuroendocrine tumors of the stomach only can be well completed with a view of the basic characteristics of the elements of the so-called neuroendocrine system or gastrointestinal APUD system. Therefore, these gastric neoplasias cannot be studied in isolation because they are derived from a special line of endocrine cells that have many common biochemical bonds w...

Two human colon carcinoma cell lines derived from the same tumor specimen were characterized. The cell lines, COLO 320 and COLO 321 , have amine precursor uptake and decarbox ylation cell properties, such as ectopic production of norepi nephrine, epinephrine, serotonin, adrenocorticotropic hor mone, and parathyroid hormone. The cells were morphologi cally different from most colon cell lines. D...

The monoclonal antibody NK1 C3, synthesised by the Netherlands Cancer Institute, has been used to assess its value in the diagnosis of melanocytic lesions. The antigen recognised by this antibody is not denatured by formalin fixation, with the result that the antibody can be used for retrospective studies on conventionally processed material. Positive results were obtained in primary melanoma (...

Somatostatin receptor scintigraphy (SNS) with In-labelled somatostatin receptor analog is a standard procedure for the detection and staging of neuroendocrine tumors (NETs, APUDomas). NETs can be small and situated almost throughout the body. This heterogeneous group of tumors take up amino acids, transform them into biogenic amines (dopamine and serotonin) by decarboxylation, and store the ami...