Surgical removal of body fat (lipectomy) triggers compensatory increases in nonexcised white adipose tissue (WAT), thus restoring adiposity levels in many species, including Siberian hamsters. In Siberian hamsters, when their lipectomized WAT is transplanted to another site (autologous grafts, no net change in body fat), healthy grafts result, but the lipectomy-induced compensatory increases in...

The artificial vascular grafts currently in clinical use still have problems with respect to late calcification, restenosis, antithrombotic property, durability, biocompatibility, and safety, and no ideal artificial vascular graft has been developed to date. In view of this, we have been continuing basic experimental studies and their clinical applications in an attempt to develop tissue-engine...

Trauma to the anterior cruciate ligament (ACL) is a season-ending injury and involves months of activity modification and rehabilitation. The annual incidence of ACL tears in the United States is approximately 200,000, which allows for a broad range of individualized treatment options. Various surgical techniques, including transtibial and independent tunnel drilling, allograft and autograft ti...

The objectives of this study were to evaluate healing of experimentally severed superficial digital flexor tendons of the canine hind limb repaired by apposition using a Kessler pattern with no augmentation, or augmentation with an everted autologous venous graft or non-everted autologous venous graft. A total of 30 healthy, orthopaedically and neurologically sound mongrel dogs were used in thi...

The use of autografts versus allografts for anterior cruciate ligament (ACL) reconstruction is controversial. The current popular options for ACL reconstruction are patellar tendon or hamstring autografts, yet advances in allograft technologies have made allogeneic grafts a favorable option for repair tissue. Despite this, the mismatched biomechanical properties and risk of osteoarthritis resul...

Human adipose tissue represents an abundant, practical and appealing source of donor tissue for autologous cell replacement. Recent findings have shown that stem cells within the stromalvascular fraction of adipose tissue display a multilineage developmental potential. Adipose tissue-derived stem cells can be differentiated towards adipogenic, osteogenic, chondrogenic,myogenic and neurogenic li...

Heart disease and atherosclerosis are the leading causes of morbidity and mortality worldwide. The lack of suitable autologous grafts has produced a need for artificial grafts; however, current artificial grafts carry significant limitations, including thrombosis, infection, limited durability and the inability to grow. Tissue engineering of blood vessels, cardiovascular structures and whole or...

AIM The aim of this study was to evaluate the healing of autologous bone block grafts or deproteinized bovine bone mineral (DBBM) block grafts applied concomitantly with collagen membranes for horizontal alveolar ridge augmentation. MATERIAL AND METHODS In six Labrador dogs, molars were extracted bilaterally, the buccal bony wall was removed, and a buccal box-shaped defect created. After 3 mo...

Autoiogous bone marrow transplantation (BMT) ~ is being evaluated at several medical centers as an alternative approach to aliogeneic BMT for the t rea tment of acute lymphoblastic leukemia (ALL) patients who do not have matched sibling donors (1, 2). A major limitation o f autologous B M T is the likely presence o f residual leukemia in the remission marrow (2). This difficulty makes ex vivo p...

BACKGROUND Autologous nerve grafts are used to bridge peripheral nerve defects. Limited sources and donor site morbidity are the major problems with peripheral nerve grafts. Although various types of autologous grafts such as arteries, veins and muscles have been recommended, an ideal conduit has not yet been described. AIMS To investigate the effectiveness of a small intestinal conduit for p...