Cephalotaxus mannii Hook.f is a rare medicinal plant used for the treatment of leukemia, however, its fungal endophytes with antibacterial and anticancer properties have not been exploited yet. In this study, six isolates were recovered from roots C. collected in Ha Giang province, Vietnam. Among them, ethyl acetate crude extract strain WQF5 exhibited strong activity against 5 tested pathogens ...

In this study we show that diindolylmethane (DIM) induces autophagy in ovarian cancer cells by regulating endoplasmic reticulum (ER) stress and AMPK. Treatment of SKOV-3, OVCAR-3 and TOV-21G ovarian cancer cells with varying concentrations of DIM for 24 hours resulted in a concentration dependent induction of autophagy as measured by flowcytometry. Electron microscopy confirmed the presence of ...

Paclitaxel (PTX), a widely used anticancer agent, is found in the inner bark of several Taxus species, although at such low levels that its extraction ecologically unsustainable. Biotechnological platforms based on sp. cell cultures offer an eco-friendlier approach to PTX production, with yields can be improved by elicitation. However, also limited excretion target compounds from producer cells...

Abstract Purpose An endangered Tsuga chinensis (Franch.) Pritz. is widely used as a natural medicinal herb in many countries, but little has been reported on its culturable endophytic fungi capable of producing secondary metabolites applied modern medicine and pharmacy. The present study aimed to evaluate the distribution fungal endophytes their cytotoxic antioxidant properties. Methods This su...

We report the synthesis of BaPt2As2 single crystals and the discovery of superconductivity and a structural phase transition in this compound by measuring the electrical resistivity, magnetic susceptibility and specific heat as well as the X-ray diffraction at low temperatures. BaPt2As2 crystallizes in the CaBe2Ge2-type tetragonal structure (P4/nmm) at room temperature and undergoes a first-ord...

1 Murray HW, Masur H, Senterfit LB, Roberts RB. The protean manifestations of Mycoplasma pneumoniae infection in adults. AmJ Med 1975; 58: 229-42. 2 Tuazon CU, Murray HW. Atypical pneumonias. In: Pennington JE, ed. Respiratory infections: diagnosis and management. 2nd ed. New York: Raven Press, 1988: 346. 3 Salzman MB, Sood SK, Slavin ML, Rubin LG. Ocular manifestations of Mycoplasma pneumoniae...