BARBITURIC acid was first synthesized by Conrad and Guthzeit in 1882, and in 1903 the 5:5-diethyl derivative was introduced into medicine as a hypnotic by Carl Fischer and von Mering, under the name of Veronal. In the past, barbituric acid was usually regarded as the cyclic ureide of malonic acid, i.e. as malonyl urea, and its structural formula written in a form which emphasized this relations...

A series of arylidine barbituric acid derivatives was synthesized by Knoevenagel condensation reaction of aromatic aldehydes with barbituric acid or thiobarbituric acid using dodecylbenzenesulfonic acid as a Brønsted acid-surfactant catalyst in aqueous media. Regardless of the nature of the substitution (electron-donating and -withdrawing), all the reactions were completed within 15-65 min in w...

Yeehaw! The rotation of a visible-light-driven molecular motor based on barbituric acid is tamed by hydrogen bonding “lasso” mechanism between its serendipitously-formed tertiary hydroxy stereocentre and lower half carbonyl groups.

The; treatment of certain types of mental disorder by artificial sleep maintained over a considerable period?8 to 10 days?was first introduced by Klaesi of Zurich in 1920. Since then this form' of treatment has been widely adopted in Europe?except, perhaps, in England ?and many observers have published their results. The drug that has been used most extensively for this purpose has been Somnife...

The retention time of 23 barbituric acid derivatives was determined on an narrow-bore porous graphitized carbon (PGC) column employing water-dioxane mixtures as mobile phases. The retention factor (k), theoretical plate number (N), and asymmetry factor (AF) were computed for each analyte in each mobile phase. Quantitative structure-retention relationship (QSRR) calculations using stepwise regre...

Known as a Lewis acid which acts as a natural catalyst, bentonite can be used to produce several arylidene  (thio) barbituric  acid  derivatives  through  conducting  a  Knoevenagel  reaction  between aromatic aldehydes and (thio) barbituric acid. Water is considered as the medium for this reaction and the results are at arange of good to excellent over a reasonable reaction time. This method i...

An earlier study (1) from this laboratory proved conclusively that Amytal, 5-ethyl-5-isoamylbarbituric acid (I), is not detoxified by simple hydrolysis of the barbituric acid ring and indicated that the alkyl side chain (or chains) must suffer alteration in viva. Recently (2), it was discovered that the isomeric drug, pentobarbital, is excreted as the diastereoisomers of 5-ethyl-5-(3-hydroxy-1-...

Cases are admitted from time to time to most large hospitals in a state of coma or semi-coma in which the differential diagnosis includes overdosage with the barbiturate series of narcotic drugs. It is often important to confirm or exclude this factor as quickly as possible. Standard methods of analysis (e.g., the Stas-Otto process, Smith, 1934a), although ultimately giving accurate quantitativ...