PURPOSE Anaplastic thyroid cancer (ATC) is a rare but lethal malignancy without any effective therapy. The aim of this study is to use a high-throughput drug library screening to identify a novel therapeutic agent that targets dysregulated genes/pathways in ATC. EXPERIMENTALDESIGN We performed quantitative high-throughput screening (qHTS) in ATC cell lines using a compound library of 3,282 dr...

Background In response to the financial crisis and under the EU/IMF Programme of Financial Support, Ireland committed to make savings on pharmaceutical expenditure, including through a system of generic substitution (GS) and reference pricing (RP) [1]. This intervention involved GS based on fifth level ATC code (active substance), which was followed by RP 3-5 months later. The aim of this analy...

Anaplastic thyroid carcinoma (ATC) is one of the most lethal carcinoma with a poor prognosis; however, molecular mechanisms underlying the aggressiveness of ATC remain unclear. Our goal was to examine the expression of X-linked inhibitor of apoptosis protein (XIAP) in ATC, as well as its role in ATC tumorigenesis. This is a retrospective study of ATC patients from the Second Affiliated Hospital...

Ron Courson, ATC, PT, NREMT-I, CSCS (Chair)*; Michael Goldenberg, MS, ATC (Chair)*; Kevin G. Adams, CAA†; Scott A. Anderson, ATC‡; Bob Colgate§; Larry Cooper, MS, LAT, ATC*; Lori Dewald, EdD, ATC, MCHES, F-AAHE||; R.T. Floyd, EdD, ATC*; Douglas B. Gregory, MD, FAAP¶; Peter A. Indelicato, MD#; David Klossner, PhD, ATC**; Rick O’Leary, MS, ATC, AT/L*; Tracy Ray, MD††; Tim Selgo‡‡; Charlie Thompso...

It is extremely difficult to realize two conflicting properties-high hardness and toughness-in one material. Nano-polycrystalline stishovite, recently synthesized from Earth-abundant silica glass, proved to be a super-hard, ultra-tough material, which could provide sustainable supply of high-performance ceramics. Our quantum molecular dynamics simulations show that stishovite amorphizes rapidly...

OBJECTIVES To evaluate the suitability of the ATC/DDD Index (Anatomical Therapeutic Chemical (ATC) Classification System/Defined Daily Dose) for analyzing prescription lists in the U.S. METHODS We mapped RxNorm clinical drugs to ATC. We used this mapping to classify a large set of prescription drugs with ATC and compared the prescribed daily dose to the defined daily dose (DDD) in ATC. RESU...

BACKGROUND Assistive technology for cognition (ATC) can be defined as external devices aimed at supporting cognitive function. Studies in neurological populations suggest that use of ATC is a promising strategy to ameliorate negative effects of cognitive impairment and improve Health-related Quality of Life (HRQoL). There is a lack of studies on the effects of ATC in HD. OBJECTIVE This study ...

Analytical Target Cascading (ATC) is a product development tool that computes component design specifications such that the final system design is consistent and meets design targets. ATC is useful for complex product design that must be approached by decomposition, and facilitates concurrent design activities. While ATC has been applied successfully to automotive design, this article introduce...

Abstract Background Rare diseases are life-threatening, serious, and chronic conditions that require complex care have a low prevalence. An estimated one in 15 people worldwide affected by rare diseases. This study aims to analyze the accessibility, reimbursement status, licensed Anatomical Therapeutic Chemical (ATC) codes of drugs European Medicines Agency (EMA) Turkey considers be “orphan” ph...

Aim. Analysis and systematization of the main market trends development in pressurized pharmaceutical preparations veterinary practice. Materials methods. Methods systematic approach, bibliographic methods, information retrieval, analysis, comparison generalization, statistical processing, tabular graphic means visual presentation obtained data were used during research. The analysis registered...