BACKGROUND Bisphenol A as an endocrine-disrupting chemical is widely used chemical in the manufacture of polycarbonate plastics and epoxy resin and has become ubiquitous environmental contaminants. Human exposure to Bisphenol A is widespread and recent studies have been shown to be associated with a higher risk for self-reported adverse health outcomes that may lead to insulin resistance and th...

Antioxidants can inhibit atherosclerosis, but it is unclear how inhibition of intimal lipid oxidation relates to atherogenesis. Here we tested the effect of probucol and its metabolite bisphenol on aortic lipid (per)oxidation and atherogenesis in Watanabe heritable hyperlipidemic (WHHL) rabbits. LDL and aortas from rabbits fed probucol contained bisphenol at concentrations comparable to those i...

Implications for human health of the extensive bisphenol A literature showing adverse effects at low doses: A response to attempts to mislead the public Bisphenol A is the chemical monomer used in the manufacture of resins that line cans, polycarbonate plastic (including many food and beverage containers), and as an additive in many other products. We respond here to an article published in Tox...

AIMS To evaluate effects of exposure to bisphenol A diglycidyl ether (BADGE) on urinary excretion of bisphenol A, and plasma gonadotrophic hormones and testosterone in male epoxy resin sprayers. METHODS Cross sectional study of 42 workers whose job was to spray epoxy resin hardening agents including BADGE and mixed organic solvents, and 42 matched control workers without BADGE use in the same...

this study was conducted to reveal the estrogenic effects of bisphenol a and o, p’-ddt on quailembryos. thirteen fertilized eggs were used as control (injected with 20 μl corn oil), 15 eggs were injectedwith estradiol 17β (0.04 mg dissolved in 20 μl corn oil), 20 eggs were injected with bpa (2 mg dissolved in20 μl corn oil) and 20 eggs were injected with o, p’-ddt (2 mg dissolved in 20 μl corn ...

Neonatal exposure of rats to bisphenol-A, an endocrine disruptor, has recently been proposed as a possible animal model of attention-deficit hyperactivity disorder, because such rats exhibit motor hyperactivity and impaired habituation to a novel environment 4-5 weeks after bisphenol-A pretreatment. To extend the original experiments, the present study additionally analyzed the effects of neona...

Various adverse effects of endocrine disruptors on the reproductive organs of male animals have been reported. We found that UDP-glucuronosyltransferase (UGT) activities towards bisphenol A, testosterone and oestradiol were significantly decreased in liver microsomes prepared from adult male Wistar rats administered with the endocrine disruptor bisphenol A (1 mg/2 days for 2 or 4 weeks). Howeve...

Bisphenol A is an industrial chemical widely used in plastic products with a consequent exposure to humans. To assess whether exposure to bisphenol A is associated with renal disease, we searched for low-grade albuminuria in 3055 Chinese adults in the Shanghai metropolitan area aged 40 years or older. Using a value for urinary albumin-to-creatinine ratios <30 mg/g, we examined its association w...