membrane permeability and p-glycoprotein (p-gp) efflux system are regulating factors in the drug brain penetration. recently, some drug delivery systems have been developed to overcome these limitations. in this study, metoclopramid has been encapsulated in plga nanoparticles using the emulsification/solvent evaporation technique for in vitro evaluation of the effect of plga nanoparticles on bb...

Introduction: Recent studies suggest that dietary virgin olive oil (VOO) reduces hypoxia-re oxygenation injury in rat brain. We have attempted to determine the effect of dietary virgin olive oil on brain lipidomics and its relationship with brain edema in a rat stroke model. Methods: Five groups, each consisting of 6 male Wistar rats, were studied. The first and second groups (control and s...

multiple sclerosis (ms) is one of the most important autoimmune diseases recognized by demyelination and axonal lesion. it is the most common cause of disability in the young population. various immunomodulatory and immunosuppressive therapies, including different formulations of interferon beta (ifnβ), glatiramer acetate (ga), mitoxantrone, and natalizumab are available for this disease. howev...

background: nitric oxide synthase (nos) activity is increased during hypertension and cerebral ischemia. nos inactivation reduces stroke-induced cerebral injuries, but little is known about its role in blood-brain barrier (bbb) disruption and cerebral edema formation during stroke in acute hypertension. here, we investigated the role of nos inhibition in progression of edema formation and bbb d...

Blood–Brain Barrier Therapy The blood–brain barrier (BBB) is a bottleneck in the treatment of brain tumors. In article number 2203678, Liang Wang, Yinyan Lin Feng, and co-workers summarize current approaches to overcome BBB, such as use “Trojan horse” molecular modifications for deception, describe variety micro-nanocarriers targeted tumor therapy.