In the present study, aqueous solutions of some copper-complexing ligands were screened for their cytotoxicity using brine shrimp lethality test. Among the ligands tested, diacetyl-bis(N4-methylthiosemicarbazones) (ATSM) proved to be the most safe and non-toxic compound (2% lethality at 10 ppm), while pyruvaldehyde Bis(N4-methyl)thiosemicarbazone (P...

ABSTRACT: Candidiasis is a fungal infection caused by Candida albicans. Allium sativum (garlic) and Curcuma longa (turmeric) have been used as antifungal agents. The main aim of this study was to identify the effectiveness of these natural products towards C. albicans and on their pharmacological and toxicity aspects. Thus, agar disc diffusion method was used to study the antifungal activity of...

Sesbania Grandiflora (Family: Leguminosae) is a medicinal plant used as tumor suppressant agent in Ayurveda, a traditional system of medicine practiced in sub-continental India. The aim of the study was to systematically investigate and reveal the cytotoxic potential of sesbania grandiflora bark extract [petroleum ether (BP), Chloroform (BC), Methanol extract (BM) and Aqueous extract (BA)] agai...

Water and alcoholic extracts of Crotalaria juncea L. plant were tested for their antimicrobial properties in vitro against some selected human pathogenic bacteria such as Pseudomonas aeruginosa, Escherichia coli, and Staphylococcus aureus by agar well diffusion method and were subjected to brine shrimp lethality assay to detect their cytotoxic ability. In addition, the anticancer properties of ...

general toxicity, antiproliferative, antibacterial and antioxidant activities of caulerpa peltata j.v.lamouroux (caulerpaceae) collected from oman sea were investigated. dried, ground alga was soxhlet-extracted with hexane, dichloromethane and methanol successively. the methanol extract was subjected to vacuum liquid chromatography (vlc) fractionation on silica gel using a step gradient of diff...

The organic extracts of leaves and roots of five plants used for treating malaria in Central, Nairobi and Rift Valley Provinces, Kenya were tested for brine shrimp lethality and in vitro antiplasmodial activity against chloroquine sensitive and resistant strains of Plasmodium falciparum. Of the plants tested, 60% were toxic to the brine shrimp (LC(50)<30 microg/ml) and eight out of ten plant pa...

OBJECTIVE To investigate the toxicity of methanol extract of various parts (Root, Stem, Leaf, Flower and Fruit) of Lantana camara (L. Camara) in Artemia salina. METHODS The methanol extracts of L. camara were tested for in vivo brine shrimp lethality assay. RESULTS All the tested extract exhibited very low toxicity on brine shrimp larva. The results showed that the root extract was the most...

This research paper presents findings of an investigation about antibacterial effect of methanol/water fractions as well as cytotoxic activity of the extracts obtained from Pedicularis wilhelmsiana (Scrophulariaceae) which grows in Azarbaijan/Iran by agar well diffusion method and brine shrimp lethality test successively. Phytochemical study of this plant was determined as well. A combination o...

A well known anti-cancer lignan arctiin has not been studied for its antibacterial activity based on our literature search. In the present work, the antibacterial and general toxicity of the arctiin from the seeds of Centaurea sclerolepis is studied. Arctiin did not show any significant antibacterial activity against both Gram-positive and Gram-negative bacteria when compared with the positive ...

Marine algal community signifies a huge source of compound endowed with ingenious structure and potential biological activities. Cytotoxicity of plant or fungal material is considered as the presence of antitumor compounds. In this study, ethanol extracts of seaweeds Dictyota dichotoma var. velutricata, D. hauckiana, D. indica, Iyengaria stellata, Jolyna laminarioides, Melanothamnus afaqhusaini...