background : e-cadherin is a trans-membrane glycoprotein that plays a critical role in many aspects of cell adhesion as well as establishment and maintenance of epithelial cell polarity. loss of the adhesive function of e-cadherin seems to promote invasive and metastatic properties of neoplastic cells.   objectives: the present study is a retrospective study aiming to evaluate the loss of e-cad...

Objectives: E-cadherin is a transmembrane glycoprotein, which is responsible for cell adhesion and its expression decreases in dysplastic lesions. This study aimed to assess the expression of this marker in oral lichen planus (OLP) with and without dysplasia to assess its potential for use as a predictor of malignant transformation. Methods: This descriptive, cross-sectional study w...

E-cadherin is among tumor suppressor genes which mostly subjects to the down-regulation in squamous cell carcinoma of esophagus (SCCE). The gene is tightly associated with the tumor invasion and metastasis in multiple human cancers, especially SCCE. CpG islands’ methylation in the promoter region of E-cadherin is among the mechanisms that have been suggested for the E-cadherin silencing, howeve...

Background and objectives:  Gastric cancer is currently known as one of the most important causes of cancer-driven death all over the world. In patients with gastric cancer, a significant proportion of death occurs due to metastasis. On the other hand, down modulated E-cadherin level has been reported as an important contributor to tumor cell invasion and metastasis. In this re...

SummaryBackground: Hair follicles are produced in a cyclical manner and the machinery involved reproduction of these is present since fetal stage. Although extensive research has been done on human hair follicle, very little known about importance adhesion molecules its development. Methods: We analyzed here, immunoexpression beta-1 integrin, p-cadherin, e- cadherin, beta-catenin from 26 formal...

background gastric dysplasia (gd) is a precursor lesion of gastric adenoâ­carcinoma. intestinal type gastric carcinoma commonly shows microsatellite instability (msi) and the diffuse type is associâ­ated with down regulation of e-cadherin. her-2/neu is over-expressed in some cases of gastric cancer. in this study, msi and expression rates of her-2/neu and e-cadherin in gd were evaluated. me t h...