anti-inflammatory activity has been reported for a few of antidepressant drugs and in contrary sertraline has potentiated inflammation. in this study, anti-inflammatory effect of a collection of antidepressant drugs belonging to different classes was evaluated to help a rational selection of these drugs in disease conditions such as association of depression or anxiety with inflammatory disease...

Aim: In this study, oxidative stress, antioxidant response and inflammation parameters were investigated in intact and carrageenan-inflamed paw tissues in intact and adrenalectomized rats. The effects of prednisolone and adrenaline on these parameters were investigated. Materials and Methods: 37 Albino Wistar male rats were divided into six groups as follows: I: only adrenalectomized, II: adren...

Activins are proinflammatory cytokines which belong to the TGFβ superfamily. Follistatin is an extracellular decoy receptor for activins. Since both activins and follistatin are expressed in articular cartilage, we hypothesized that activin-follistatin signaling participates in the process of joint inflammation and cartilage degeneration. To test this hypothesis, we examined the effects of foll...

The effects of methanol extract of Phyllanthus amarus on different phases of in lammation were examined. Investigations were performed using different phlogistic agents-induced paw e ema, carrageenan-induced airpouch inflammation and cotton pellet granuloma in rats. Methanol extract of Phyllanthus amarus significantly inhibited carrageenan, bradykinin, serotonin and prostaglandin E1-induced paw...

BACKGROUND Although considerable evidence indicates neuronal Ca channels play significant roles in pain perception, their possible importance in hypersensitization after acute inflammation has not been investigated. METHODS Using carrageenan for inducing hypersensitization, the authors investigated the analgesic effects of intrathecally administered N- and P/Q-type channel blockers, omega-con...

OBJECTIVE Although electroacupuncture (EA) therapy is used to relieve various kinds of pain, the optimal frequency and duration of EA remain unclear. We investigated the effect of varying frequency and duration of EA during hyperalgesia elicited by carrageenan-induced inflammation. METHODS Carrageenan was administered by subcutaneous intraplantar injection to induce inflammation. Nociceptive ...

The peroxisome proliferator-activated receptor(PPAR) is a member of the nuclear receptor superfamily of ligand-dependent transcription factors related to retinoid, steroid, and thyroid hormone receptors. The aim of the present study was to evaluate the role of the PPARreceptor on the development of acute inflammation. To address this question, we used two animal models of acute inflammation (ca...

This study aimed to evaluate Helychrisum faradifani hydro alcoholic extract activity on the vascular and cellular phases of inflammation in mice. Carrageenan was injected hind-paw effect edema acetic acid 0.6 % by intra peritoneal route H. permeability. Cotton pellets imbibed with 1% carrageenan inserted skin animals investigate granuloma formation. Indomethacin at dose 10 mg/kg administered or...

The present investigation deals with the in-vivo acute toxicity studies and in-vivo anti-inflammatory activity by Carrageenan induced rat paw edema model of methanolic extract in the stems of Cissus Vitiginea. The Literature review reveals the presence of steroids, flavonoids, triterpenoids, and glycosides in Cissus Vitiginea. Some plants belonging to Cissus genus have been reported to possess ...