BACKGROUND Biological purity of dialysis water is considered as one of the primary conditions to deliver optimal haemodialysis. METHODS The present study explores the added value of a novel cytokine (IL-1ss) induction assay, using a monocytic THP-1 cell line, compared to the classical detection methods for microbial dialysis fluid contaminants. RESULTS In contrast to the Limulus Amebocyte L...

In the mid-1980s, limits and side effects of contemporary hemodialysis were basically due to short treatment time, use of low-flux membranes and employment of acetate-buffered dialysate. These were already associated with a relatively high morbidity and cardiovascular mortality as part of diaysis-related pathology. Based on these considerations, the concept of on-line hemodiafiltration (HDF) wa...

The central dialysis fluid delivery system (CDDS) simplifies the maintenance and supervision involved by enabling the combined management of dialysis fluid for multiple persons, preparation of cleaning and antiseptic solutions, and delivery of these to each patient monitor. The CDDS has been used exclusively in Japan since 1960s. Approximately 88 % of dialysis machines are patient monitors with...

OBJECTIVE To assess the in vivo peritoneal inflammatory reaction in rats dialyzed with neutral, bicarbonate-lactate-buffered dialysis fluid. METHODS Chronic peritoneal dialysis was performed for 4 weeks in Wistar rats with two solutions: (1) 40 mmol/L lactate-buffered fluid, pH 5.2, with a glucose concentration of 2.27 g/dL (Lac); and, (2) 15 mmol/L lactate and 25 mmol/L bicarbonate-buffered ...

BACKGROUND Cardiovascular mortality is high in hemodialysis (HD) patients. Early arterial pressure wave reflections predict mortality in HD patients, and HD acutely improves the central pressure waveform. Potassium (K) plays a crucial role in cardiac electrophysiology, and patients with end-stage kidney disease depend on HD for neutral K balance. We aimed to study the impact of dialysate K conc...

1. In eight patients being treated by chronic dialysis the relation of magnesium metabolism to the magnesium concentration of the dialysate was investigated. During four periods of 2-6 weeks the magnesium concentrations of the dialysis fluid were 0'44±0'15 mg/IOO ml, 0'70±0'24 mg/IOO ml, 1'83±0'18 mg/IOO ml and 1'97±0'21 mg/IOO ml. 2. During all periods the concentration of plasma magnesium and...

Low dialysate sodium concentrations have been associated with intradialytic symptoms such as muscle cramps and hypotensive episodes. High dialysate sodium concentrations lead to sodium loading, thirst and subsequent increase in interdialytic weight gain and hypertension. The optimal dialysate sodium concentration for an individual depends on the serum sodium concentration. The difference betwee...

Prof. M. Fischbach, Unité Nephrologie Dialyse, Transplantation, Pédiatrie 1, Hôpitaux Universitaires de Strasbourg Hautepierre, F-67000 Strasbourg (France) Patient Dear Sir, Microbially contaminated dialysate is a well-known risk in patients undergoing he-modialysis but today seems very infrequent. On the contrary, more attention is to take into consideration for the dialysate pyrogenic substan...