نتایج جستجو برای: cerebral cortex methamphetamine neurotoxicity

تعداد نتایج: 292796  

Journal: :Pharmacology, biochemistry, and behavior 1998
S D Friedman E Castañeda G K Hodge

Squads of rats were assayed at three intervals following MA-induced neurotoxicity to investigate the persistence of monoamine deficits, the potential for monoamine recovery, and spatial task abilities. At 48, 139, and 237 days postinjection, MA animals showed significant monoamine depletions compared with controls. Investigating percent depletions (MA/control) across time showed monoamine recov...

Journal: :The Journal of pharmacology and experimental therapeutics 2009
Marek Schwendt Angelica Rocha Ronald E See Alejandra M Pacchioni Jacqueline F McGinty Peter W Kalivas

Chronic abuse of methamphetamine leads to cognitive dysfunction and high rates of relapse, paralleled by significant changes of brain dopamine and serotonin neurotransmission. Previously, we found that rats with extended access to methamphetamine self-administration displayed enhanced methamphetamine-primed reinstatement of drug-seeking and cognitive deficits relative to limited access animals....

Objective(s): Methamphetamine is a stimulant compound that penetrates readily into the central nervous system. Repeated exposure to methamphetamine leads to damage in the dopaminergic and serotonergic axons of selected brain regions. Previous studies showed that cinnamaldehyde improved memory impairment in animals. In the present study, we aimed to elucidate the effects of cinnamaldehyde on met...

Journal: :iranian journal of science and technology (sciences) 2012
f. mashayekhi

in this review the role of cerebrospinal fluid (csf) in mammalian cerebral cortex development has been highlighted. many studies have focused on the potential role of the csf in the developmental process. in particular, the cerebral cortex develops from the germinal epithelium adjacent to the csf. csf contains proteins, growth factors and other neurotrophic factors which are important for neura...

Journal: :The international journal of neuropsychopharmacology 2013
Michael J Seminerio Rolf Hansen Nidhi Kaushal Han-Ting Zhang Christopher R McCurdy Rae R Matsumoto

Sigma (σ) receptors have recently been identified as potential targets for the development of novel therapeutics aimed at mitigating the effects of methamphetamine. Particularly, σ receptors are believed to mitigate some of the neurotoxic effects of methamphetamine through modulation of dopamine, dopamine transporters and body temperature. Furthermore, recent evidence suggests that targeting σ ...

2012
Reem K. Jan Rob R. Kydd Bruce R. Russell

Methamphetamine (MA) is a potent psychostimulant drug whose abuse has become a global epidemic in recent years. Firstly, this review article briefly discusses the epidemiology and clinical pharmacology of methamphetamine dependence. Secondly, the article reviews relevant animal literature modeling methamphetamine dependence and discusses possible mechanisms of methamphetamine-induced neurotoxic...

ژورنال: اعتیاد پژوهی 2016

Objective: The present study was an attempt to examine the effect of repetitive Transcranial magnetic stimulation (rTMS) on the reduction of Behavioral Activation System's activity in right and left dorsolateral prefrontal cortex among methamphetamine abusers. Method: In the present study, single subject and multiple baseline research designs were used and repeated measurements observations wer...

Journal: :سلول و بافت 0
هما محسنی کوچصفهانی دانشگاه خوارزمی تهران، دانشکده علوم زیستی، گروه علوم جانوری، تهران، ایران محمد نبیونی دانشگاه خوارزمی تهران، دانشکده علوم زیستی، گروه سلولی مولکولی، تهران، ایران سیده سمیرا مرتضوی اصل دانشگاه خوارزمی تهران، دانشکده علوم زیستی، گروه علوم جانوری، تهران، ایران زهرا نظری دانشگاه خوارزمی تهران، دانشکده علوم زیستی، گروه علوم جانوری، تهران، ایران فاطمه امیری دانشگاه خوارزمی تهران، دانشکده علوم زیستی، گروه علوم جانوری، تهران، ایران

aim: aquaporin4 (aqp4) is the main water channel in the brain that has important role in water transport across blood- brain- barrier. it has been proved that intracranial pressure and also expression of aqp4 increase in some disorders such as hydrocephalus, hyponatremia, cytotoxic oedema and brain tumours and drugs that can decrease the expression of this aqp can offer some treatment for these...

Journal: :Toxicologic pathology 2000
S J Duffell A R Soames S Gunby

In 2 studies, a method of linear morphometry was applied to regulatory developmental neurotoxicity studies in the rat. The first study involved the development of the brain during postnatal days (PNDs) 7-63, and the second involved the effects of 8 mg/kg i.p. trimethyltin chloride (TMT) to rats at PND 8, with morphometry performed at PNDs 12 and 24. The results of the TMT linear morphometry wer...

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