Human papillomavirus (HPV) can induce cervical intraepithelial neoplasia (CIN). Vaccination against HPV can play an important role in CIN prevention. This study aims to estimate the efficacy of L1 protein vaccines (Cervarix and Gardasil) in CIN 1, 2, 3 risk reduction using meta-analysis. Relevant articles were identified by two independent researchers searching international databanks. After ap...

High safety marks were given to Merck’s human papilloma virus (HPV) vaccine Gardasil. A new study published in the journal Archives of Pediatrics and Adolescent Medicine1 looked at side effects of this vaccine in a large number of female and did not detect evidence of new safety concerns among females 9 to 26 y of age following vaccination with Gardasil. In this US government-required study, 19...

Capsomers were produced in bacteria as glutathione-S-transferase (GST) fusion proteins with human papillomavirus type 16 L1 lacking the first nine and final 29 residues (GST-HPV16L1Δ) alone or linked with residues 13-47 of HPV18, HPV31 and HPV45 L2 in tandem (GST-HPV16L1Δ-L2x3). Subcutaneous immunization of mice with GST-HPV16L1Δ or GST-HPV16L1Δ-L2x3 in alum and monophosphoryl lipid A induced s...

The role of HPV as the causative factor in cervical cancer has led to the development of the HPV vaccines Gardasil and Cervarix. These vaccines effectively protect against two HPV types associated with 70% of cervical cancer cases. Despite this success, researchers continue to develop second-generation HPV vaccines to protect against more HPV types and allow increased uptake in developing count...

Cervical cancer is a major public health concern in China. The most recent findings from the International Agency for Research on Cancer, via GLOBOCAN 2012, estimated 61 691 new cases and 29 526 women dying from the disease annually in China. The actual burden of disease may be even higher, as the GLOBOCAN estimate is based on relatively few registry sites, in areas with higher than average soc...

To the Editor: We are grateful to Griffith et al. for the opportunity to clarify this point. We intended to convey that the partners of patients with human papillomavirus (HPV)16-positive oropharyngeal cancer would be unlikely to benefit from prophylactic vaccination to prevent infection with HPV16, as they are likely to already have been exposed to this HPV type. Because both Cervarix and Gard...

Persistent infection of human papillomavirus (HPV) is the necessary cause for developing cervical cancer. Now cervical cancer is getting attention as not only early-detectable but also preventable cancer by developing vaccine for HPV. In Japan, the first HPV vaccine, "Cervarix, GlaxoSmithKline (GSK)" was licensed on October 2009 and vaccination was started on December 2009. This is the bivalent...

We herein present two cases of acute disseminated encephalomyelitis (ADEM) following vaccination against human papilloma virus (HPV). Case 1 experienced diplopia and developed an unstable gait 14 days after a second vaccination of Cervarix. Brain magnetic resonance imaging (MRI) showed an isolated small, demyelinating lesion in the pontine tegmentum. Case 2 experienced a fever and limb dysesthe...