objective(s):  although several chemical and physical methods for gene delivery have been introduced, their cytotoxicity, non-specific immune responses and the lack of biodegradability remain the main issues. in this study, hydroxyapatite nanoparticles (nps) and 1,2-dioleoyl-sn-glycero-3-phosphoethanol​amine (dope)-modified hydroxyapatite nps was coated with antisense oligonucleotide of e6 mrna...

conclusions cervical cancer screening, comprising of both pap test and hpv testing, is an essential part of the routine health care for women as it can facilitate the detection of abnormal cervical cells. hpv infection can produce abnormal pap test results; also, certain types of hpv are associated with cancer. therefore, it is important to diagnose abnormal cervical tissues before the developm...

objective(s): valproic acid (vpa) has proven to be as one of the most promising useful drug with anticancer properties.in this study, we investigate the vpa effects on e-cadherin expression in hela, tc1, mkn45, and hct116 cell lines.  this study assesses the effects of vpa on human papillomavirus e7 expression in hpv positive cell lines. materials and methods: cell lines were treated by2 mmol/l...

Background Cervical cancer is the second most common cancer in women and is regarded as one of the leading causes of cancer death in developing countries. In cervical cancer patients, both surgery and radiation therapy may bring about sexual dysfunction. Therefore, this study aimed to survey sexual dysfunction in women with cervical cancer and a history study of pelvic radiation therapy in Ghae...

objective(s):  infection by high-risk papillomavirus is regarded as the major risk factor in the development of cervical cancer. recombinant dna technology allows expression of the l1 major capsid protein of hpv in different expression systems, which has intrinsic capacity to self-assemble into viral-like particles (vlp). vlps are non-infectious, highly immunogenic and can elicit neutralizing a...

cervical cancer is the third most common cancer among women in malaysia. the objective of this study was to estimate the effect of explanatory variables on survival time of cervical cancer patients receiving treatment at a hospital in malaysia.in this retrospective record review study, cervical cancer data obtained from hospital universitisains malaysia (husm) was analysed. the data comprises o...

background cervical cancer is the fourth most common cancer among women worldwide. organized cervical screening and vaccination against human papilloma virus (hpv) have been successful interventions for prevention of invasive cervical cancer (icc). because of cultural and religious considerations, icc has low incidence in iran and many other muslim countries. there is no organized cervical scre...

abstract background and aims: cervical cancer is among leading causes of cancer related death in women and human papilloma virus (hpv) is one of the important risk factor of this cancer. the aim of the present study was to develop a pcr method for identification of a high carcinogenic type of hpv, hpv 18 using e6 gene as a marker in patients with cervical cancer materials and methods: 92 formal...