objectives: ziziphus jujube (jujube) plant has exhibited numerous medicinal and pharmacological properties including antioxidant and anti-inflammatory effects. this study was carried out to investigate its anti-cancer and pro-apoptotic abilities in human cervical and breast cancer cells in vitro. materials and methods: the cervical ov2008 and breast mcf-7 cancer cells were incubated with differ...

EVALUATION OF THE EFFECTS IBUPROFEN CYTOTOXIC DOSE ON EXPRESSION LEVEL EXTRACELLULAR MATRIX DEGRADING MMP-9 AND ANTI-METASTASIS NM23 GENES IN CERVICAL CANCER CELLS

female cancer, especially breast and gynecologic cancers are considered multistage disease, highly influenced by risk and protective factors and/or screening preventive modalities. consequences of all these factors result in the trend of change over time.in this comparative study, based on data of national cancer registry of iran 2004 published by iranian ministry of health, age - standard inci...

background: cervical cancer is one of the most common types of women’s reproductive cancers. a major risk factor for cervical cancer is exposure to a group of common sexually transmitted viruses called human papillomavirus  (hpv). the over expression of hpv 16 i.e., e6 antigen in the tumors of suspected cervical cancer tissues. however e-6 antigen has hyaluronan binding protein site. methods: t...

a 49 year old woman diagnosed as a cervical cancer patient, after receiving appropriate treatment experienced metastasis in her abdominopelvic cavity. after aggressive management, she was well for a while. however, she developed to a poor condition consisting of urologic, gastroenterological, hematologic and neurologic problems just in a short time. in the course of hospital she presented one s...

background and aim: carcinoma of the uterine cervix is a significant cause of mortality because of malignancy in women. radiotherapy is a major treatment modality for invasive cervical cancer with good treatment outcome in early-stage patients. however, substantial treatment failures still occur in the advanced-stage patients. in this case report a long term follow up of a 58 years old woman wi...

Background: Human papillomavirus (HPV) is responsible for the development of cervical neoplasia.  Infection with human papillomavirus type 16 (HPV-16) is a major risk factor for the development of cervical cancer. The virus encodes three oncoproteins (E5, E6 and E7), of which, the E7 oncoprotein is the major protein involved in cell immortalization and transformation o...

Therapeutic potential of harmaline, a novel alkaloid, against cervical cancer cells in vitro: Apoptotic induction and DNA interaction studyParomita Bhattacharjee, Sarita Sarkar, Tapas Ghosh, Kakali Bhadra