A simple, accurate reverse phase high-performance liquid chromatographic method was developed and validated for the simultaneous estimation of Amitriptyline and Chlordiazepoxide in bulk and pharmaceutical dosage forms. Chromatography was carried out by using Chromosil C-18, column having 250 x 4.6mm internal diameter with a mixture of Methanol: Acetonitrile 70:30 (V/V) as mobile phase. Determin...

Anxiolytic benzodiazepines, at low doses, reportedly impair the radial arm maze with nonspatial visual/tactile but not spatial cues. We replicated the former result controlling for changes in drug state and cue effectiveness. Rats learned an eight-arm radial maze with reward in only four arms. The reward varied in spatial position from trial to trial but was always cued by a piece of sandpaper ...

OBJECTIVE To assess the effect of an individualized treatment regimen on the intensity and duration of medication treatment for alcohol withdrawal. DESIGN A randomized double-blind, controlled trial. SETTING An inpatient detoxification unit in a Veterans Affairs medical center. PATIENTS One hundred one patients admitted for the treatment of alcohol withdrawal who could give informed conse...

The zolpidem discriminative cue is mediated by GABA(A)-alpha1 receptors, whereas the chlordiazepoxide cue may be mediated via non-alpha1 GABA(A) receptors because compounds with selective affinity for GABA(A)-alpha1 receptors fully generalize to the former cue. We predicted that L-838,417 [7-tert-butyl-3-(2,5-difluorophenyl)-6-(2-methyl-2H-1,2,4-triazol-3-ylmethoxy)-1,2,4-triazolo[4,3-b]pyridaz...

Benzodiazepines such as chlordiazepoxide (CDP) promote feeding in a number of species. This effect has been interpreted generally to be an indirect consequence of benzodiazepine anti-anxiety action, although some have questioned whether it might not reflect instead a direct action upon the reinforcing properties of foods. The present study employed a behavioral measure that can discriminate bet...

-The effects of meprobamate, chlordiazepoxide, diazepam and sodium pentobarbital on sensory input to the boundary area between the dorsal midbrain tegmentum and ventral tectum of the rat have been investigated in order to find out whether effects obtained with these compounds in the hypothalamus can also be observed at the mesencephalic level. The following results have been obtained. (1) At a ...

angiogenesis which is the recruitment of new blood vessels is a critical process in several chronic diseases and is an essential component of tumor or cancer progression. development of therapies aimed at inhibiting the angiogenesis, in combination with classical anti-cancer therapies, is among the most intensively studied approaches to treat the cancer. in this study the effect of chlordiazepo...