conclusions this study revealed allele frequency of some strs on chromosome 12 and 16 for the first time in iran, and indicated differences between subjects with metabolic syndrome and subjects in the control group. results there was no significant deviation in allelic frequencies from hardy-weinberg equilibrium for all the studied markers except for d12s1632 and d12s329. the long alleles in d1...

Somatic cell hybrids between mouse and human corneal stroma fibroblasts have been used to identify the human chromosome responsible for the synthesis of human corneal type I procollagen. Twenty-six separate hybrid clones and subclones from three separate hybridization events were isolated in hypoxanthine-aminopterin-thymidine (HAT) selection medium and were used to assay for the production of h...

genome-wide association studies (gwas) have identified genetic variants contributing to the risk of cardiovascular disease (cvd) at the chromosome 9p21 locus. the chromosome 9p21 is an important susceptibility locus for several multifactorial diseases like ischemic stroke, aortic aneurysm, type 2 diabetes mellitus and coronary artery disease (cad). f7 gene because of its role in activating the ...

Like the biological clock in the body, replication of each cell type (even different cells of the same organism) follows a timing program. Abnormal function of this timer could be an alarm for a disease like cancer. DNA replication starts from a specific point on the chromosome that is called the origin of replication. In contrast to prokaryotes in which DNA replication starts from a single ...

Recessive dystrophic epidermolysis bullosa (RDEB) is a cutaneous genetic disease, which characterized by the loss of functional type VII collagen. The epidermis becomes extremely fragile without collagen, and patients suffer from repetitive blistering scar formation. RDEB caused mutations in COL7A1 gene (coding collagen), most have two different on each gene. Interestingly, it known that part s...

Gain or loss of chromosomes resulting in aneuploidy can be important factors in cancer and adaptive evolution. Although chromosome gain is a frequent event in eukaryotes, there is limited information on its genetic control. Here we measured the rates of chromosome gain in wild-type yeast and sister chromatid cohesion (SCC) compromised strains. SCC tethers the newly replicated chromatids until a...