Clindoxyl Gel (Stiefel) is a combination of 1% clindamycin phosphate and 5% benzoyl peroxide in a gel vehicle that is well tolerated and more efficacious than either active agent alone or the vehicle in reducing lesion counts and improving global scores in patients with moderate acne. It was approved for once daily use in Canada in November 2001.

BACKGROUND Acne vulgaris is a chronic disease with several pathogenic factors. Multiple medications are typically used that can lead to nonadherence and treatment failure. Combination medications target multiple pathways of acne formation and may offer therapeutic benefit. PURPOSE To explore the efficacy and tolerability of combination retinoid plus antimicrobial treatments in acne vulgaris. ...

FISCHER, J.A., BLUM, J.W. & BINSWANGER, U. (1973) Acute parathyroid hormone response to epinephrine in vivo. Journal of Clinical Investigation, 52, 2434. KUKREJA, S.C., HARGIS, G.K., ROSENTHAL, I.M. & WILLIAMS, G.A. (1973) Pheochromocytoma causing excessive parathyroid hormone production and hypercalcemia. Annals of Internal Medicine, 79, 838. MILLER, S.M., SIZEMORE, G.W., SHEPS, S.G. & TYCE, G...

background it has been shown that topical nanoliposomal formulations improve burn healing process. on the other hand, it has been shown that liposomal formulations increase drug deposition in the normal skin while decrease their systemic absorption there is not such data available for burn eschar. present investigation studies permeation of clindamycin phosphate (cp) through burn eschar from li...

BACKGROUND It has been shown that topical nanoliposomal formulations improve burn healing process. On the other hand, it has been shown that liposomal formulations increase drug deposition in the normal skin while decrease their systemic absorption there is not such data available for burn eschar. Present investigation studies permeation of clindamycin phosphate (CP) through burn eschar from l...

Cellulose phosphate powder can be added to serum to selectively bind aminoglycosides by ionic interaction without binding or inactivation of the penicillins, the cephalosporins, clindamycin, vancomycin, chloramphenicol, or trimethoprim. This simple, rapid technique permits the measurement of non-aminoglycoside antibiotics in the presence of aminoglycosides.

Clindamycin phosphate is an antibiotic which is effective against both Staphylococcus aureus and the anaerobic organisms. In thirteen patients, its concentration following joint replacement was measured by the agar diffusion method. In bone, the concentration was (mean + s.e. mean) 5.01 pg/ml ± 1.16, N=10; in capsule, 3.29 pg/ml ± 0*71, N=12; measured between 1.75 and 3.75 hr after intramuscula...

Clindamycin phosphate is an antibiotic which is effective against both Staphylococcus aureus and the anaerobic organisms. In thirteen patients, its concentration following joint replacement was measured by the agar diffusion method. In bone, the concentration was (mean +/- s.e. mean) 5.01 microgram/ml +/- 1.16, N=10; in capsule, 3.29 microgram/ml +/- 0.71, N=12; measured between 1.75 and 3.75 h...