نتایج جستجو برای: clindamycin phosphate

تعداد نتایج: 107659  

Journal: :the iranian journal of pharmaceutical research 0
azadeh ghaffari department of pharmaceutics, school of pharmacy, shahid beheshti university of medical sciences, tehran, iran. ali manafi department of surgery, school of medicine, tehran university of medical sciences, tehran, iran. hamid reza moghimi department of pharmaceutics, school of pharmacy, shahid beheshti university of medical sciences, tehran, iran.

antimicrobial therapy remains to be the most important method of wound infection treatment. systemically administered antimicrobials may not achieve therapeutic level in wound. on the other hand, in the absence of surgical debridement (due to any reason), most topically applied antimicrobials cannot penetrate the wound in therapeutic amount due to the presence of eschar. burn eschar is a protei...

2003
H. COATS ALEXANDER D. ARGOUDELIS

Addition of clindamycin to whole-cell cultures of Streptomyces coelicolor MUller resulted in the loss of in vitro activity against organisms sensitive to clindamycin. Incubation of such culture filtrates with alkaline phosphatase generated a biologically active material identified as clindamycin. Fermentation broths containing inactivated clindamycin yielded clindamycin 3-phosphate, the structu...

Journal: :The Journal of antibiotics 1972
T F Brodasky C Lewis

Culture Streptomyces coelicolor Muller NRRL3532 deactivates clindamycin. The inactive compound identified as clindamycin-3-phosphate on treatment with dephosphorylating enzymes affords the active compound, clindamycin. In as much as the 2-phosphate ester of clindamycin is being clinically evaluated as an injectable form of clindamycin, it was of interest to compare its in vitro and in vivo char...

2014
Prakash B. Modi Nehal J. Shah

A novel stability-indicating RP-HPLC method was developed for the simultaneous estimation of clindamycin phosphate (hydrophilic), adapalene (hydro-phobic), phenoxyethanol, and methylparaben in topical gel formulations. Optimum chromatographic separation among the analytes and stress-induced degradants peaks was achieved on the XBridge C18 (50 × 4.6 mm, 3.5 µm) column using a mobile phase consis...

2007
M. V. RAMANA A. D. CHAUDHARI M. HIMAJA D. SATYANARAYANA KAMAL DUA

Liposomal encapsulation is known to signifi cantly improve the therapeutic index of a drug. In the present investigation liposomal formulations were chosen to transport clindamycin, which is considered as the most effective topical antibiotic for acne, into the skin layers. Liposomes with clindamycin phosphate were prepared using lipid fi lm hydration method and the optimum ratio of the compone...

Antimicrobial therapy remains to be the most important method of wound infection treatment. Systemically administered antimicrobials may not achieve therapeutic level in wound. On the other hand, in the absence of surgical debridement (due to any reason), most topically applied antimicrobials cannot penetrate the wound in therapeutic amount due to the presence of eschar. Burn eschar is a protei...

Journal: :Infectious Diseases in Obstetrics and Gynecology 1997
Ashwin Chatwani Mark Martens Jorge Blanco Stanley Gall Kira Przybylko Charles P. Wajszczuk Dana Nickens

OBJECTIVE The purpose of this study was to compare the clinical efficacy and safety of trospectomycin sulfate with that of clindamycin phosphate, both with aztreonam, for the treatment of obstetric and gynecologic infections. METHODS In a double-blind, multicenter, prospective randomized study, 579 patients with either endometritis following cesarean delivery or pelvic cellulitis following hy...

Antimicrobial therapy remains to be the most important method of wound infection treatment. Systemically administered antimicrobials may not achieve therapeutic level in wound. On the other hand, in the absence of surgical debridement (due to any reason), most topically applied antimicrobials cannot penetrate the wound in therapeutic amount due to the presence of eschar. Burn eschar is a protei...

2013
Azadeh Ghaffari Ali Manafi Hamid Reza Moghimi

Antimicrobial therapy remains to be the most important method of wound infection treatment. Systemically administered antimicrobials may not achieve therapeutic level in wound. On the other hand, in the absence of surgical debridement (due to any reason), most topically applied antimicrobials cannot penetrate the wound in therapeutic amount due to the presence of eschar. Burn eschar is a protei...

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