Background Paracetamol and Pethidine are two prevailing analgesics prescribed for postoperative orthopedic patients, each having different side effects and impacts on fracture healing. The present study was conducted to compare the impacts of Paracetamol and Pethidine on postoperative pain relief of children with bone fractures....

A narrative is a brief summary of specific events experienced by patients, during the course of a clinical trial. Narrative writing involves multiple activities such as generation of patient profiles, review of data sources, and identification of events for which narratives are required. A sponsor outsources narrative writing activities to leverage the expertise of service providers which in tu...

There is an urgent need for an improved TB vaccine. Vaccine development is hindered by the lack of immune correlates and uncertain predictive value of preclinical animal models. As data become available from human efficacy trials, there is an opportunity to evaluate the predictive value of the criteria used to select candidate vaccines. Here we review the efficacy in animal models of the MVA85A...

The identification of genetic factors that confer risk for the common forms of migraine by GWAS has given insight into the genetic underpinning of migraine pathophysiology. Still, the interpretation of the findings of GWAS is not straightforward. Various strategies are being tested to investigate which pathophysiological mechanisms are involved, how they can be studied, and what this means for ...

introduction and aims: we noticed in our practice that the patients with ulcerative colitis (uc) who have developed primary sclerosing cholangitis (psc) experience a milder course of colonic disease. our objective in this study was to define whether there is any difference between uc activity and its course in patients with and without psc. materials and methods: 19 patients with uc and psc (8 ...

This appendix draws heavily on the literature of warning and surprise and of military and technological innovation to assess Army intelligence’s tools for supporting the Army Strategic Planning System. Warning, surprise, and innovation are good analogues to use to evaluate Army intelligence assets for their appropriateness in support of the proposed decision-based planning system, for several r...

Current research shows that computer games were integral to the life of young learners across the globe. Hence, educators were looking at opportunities to use computer games in teaching and learning in order to address the needs of young learners. Meanwhile, learning needs and expectations were varied depending on the culture of a particular individual. Researches show that there were compellin...

OBJECTIVE To identify ways for improving the consistency of design, conduct, and results reporting of time and motion (T&M) research in health informatics. MATERIALS AND METHODS We analyzed the commonalities and divergences of empirical studies published 1990-2010 that have applied the T&M approach to examine the impact of health IT implementation on clinical work processes and workflow. The ...

US schools increasingly report body mass index (BMI) to students and their parents in annual fitness "report cards." We obtained 3,592,026 BMI reports for New York City public school students for 2007-2012. We focus on female students whose BMI puts them close to their age-specific cutoff for categorization as overweight. Overweight students are notified that their BMI "falls outside a healthy ...