نتایج جستجو برای: colorectal tumor
تعداد نتایج: 494611 فیلتر نتایج به سال:
Background & Objective: Since colorectal cancer does not often have phenotypic symptoms in the early stages, the study of biomarkers for the diagnosis and prognosis of the tumor is very important. MicroRNAs are one of the most important biomarkers which attract the attention of many researchers due to a variety of reasons, including their non-invasive nature; these molecules are a group of non-...
background: transcriptional silencing of tumor suppressor genes and tumor related genes like gstp1 by methylation of promotor region cpg island is believed to be an important mechanism in tumorigenesis. the gstp1 gene encodes the enzyme glutathione s-transferase pi which defends the cells against oxidative damage and electrophilic carcinogens. methods: to gain insight into the role of epigeneti...
Abstract Introduction: Colorectal cancer is the third most prevalent malignancy with high mortality rate, necessitating markers that predict survival and guide the treatment. Previous studies have examined the immunohistochemical expression of Bcl-2, an apoptotic marker, in colorectal carcinoma, but results have been contradictory. Objectives: To evaluate the histopathological featu...
objective: e-cadherin is widely down-regulated and tightly associated with tumor invasion and metastasis in multiple human cancer types. recent studies have shown that aberrant methylation of the e-cadherin gene promoter contributes to its silencing. however, information regarding epigenetic inactivation of e-cadherin in colorectal cancer is insufficient. herein, we correlate association of the...
abstract background : cancer has not been elucidated in colerectal site. c-reactive protein (crp) is a product synthesized in hepatocytes and has been reported to be up-regulated by such proinflammatory cytokines as interleukin-1 (il-1), interleukin-6 (il-6), and tumor necrosis factor (tnf). the significance of a preoperative serum elevation was evaluated using crp as a predictive indicator f...
abstract: introduction: colorectal cancer (crc) is one of the most common cancers in the world. during the past decades, survival of colorectal cancer patients has improved worldwide, however, it is not clear what factors have contributed to this development. this study was designed to evaluate the prognostic impact of a wide spectrum of pathologic parameters on survival rate in patients with...
Background: Colorectal cancer is the third most common type of aggressive cancers. Chemotherapy, surgery,and radiotherapy are the common therapeutic options for treating this cancer. Due to the adverse side-eff ects of these methods, immunotherapy is considered as an appropriate alternative therapeutic option. Treatment through the application of monoclonal antibodies is considered as a n...
Abstract Background : Cancer has not been elucidated in colerectal site. C-reactive protein (CRP) is a product synthesized in hepatocytes and has been reported to be up-regulated by such proinflammatory cytokines as interleukin-1 (IL-1), interleukin-6 (IL-6), and tumor necrosis factor (TNF). The significance of a preoperative serum elevation was evaluated using CRP as a predictive i...
Background: The molecular studies indicate some of the genes in the promoter region itself, will undergo methylation. Methylation of CpG islands in the promoter region of that cause silence or reduced expression of genes involved in cell growth pathways, which are colorectal cancer causing agents. Detection of methylation status can be used as a marker for cancer diagnosis and prediction of dis...
Introduction: Colorectal cancer is the third most common cancer in Iran. Some studies have shown that age and sex are associated with the course and prognosis of colorectal cancer. Due to the fact that recognizing the factors affecting colorectal cancer improves the screening system and selects better treatment modalities, and due to the lack of such studies in Iran, in this study, the relation...
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