In considering the question of management of labour in cases of contracted pelvis, we are considering a problem which faces us in Glasgow almost daily. Contracted pelvis, like the poor, is always with us?in fact, the incidence in this hospital varies around 15 per cent, of the total admissions to the hospital for the year. It is well known that the condition is largely a rachitic manifestation,...

In view of these contradictory findings the records of children admitted to the Royal Hospital for Sick Children during the last ten years suffering from these diseases were examined. In each case the diagnosis was established clinically and by skiagrams. The case reports and x-ray plates of 211 cases of active rickets under five years of age, fourteen cases of congenital syphilis and twenty of...

There have recently been opened, at the Hospital for Sick Children in Great Ormond Street, a new pathological and a new biochemical laboratory. In the Pathological Laboratory investigations are being made into the causes of summer diarrhoea and rickets in children. In addition, experiments are being made as to the value of the complement fixation test in tuberculosis, and as to the precipitatio...

Multiple cartilage-tipped osteomata are often congenital, hereditary, and fairly symmetrically bilateral. They occur near the growing ends of long bones in the vicinity of the epiphyseal cartilage; this gives strong support to the view that they arise in a sequestrated part, or ' rest', of the epiphyseal cartilage. They may therefore be common in cases where present or previous rickets have cau...

Abstract Objectives X-linked hypophosphatemic rickets (XLH) is a congenital fibroblast growth factor (FGF)23-related metabolic bone disease that treated with active vitamin D and phosphate as conventional therapies. Complications of these therapies include nephrocalcinosis (NC) caused by excessive urine calcium concentrations. Recently, an anti-FGF23 antibody, burosumab, was developed reported ...

Chronic hypophosphatemia is one major cause of rickets and osteomalacia in growing children (see Preface of this volume). There are acquired and congenital forms. In most instances, the acquired forms can be controlled by acting on the underlying cause (insufficient phosphate intake, increased renal loss secondary to a mesenchymal tumor, or an altered renal tubular function). The inherited synd...

a 13 year- old girl had rickets clinically evident sicne she was 10 years of age. she received multiple doses of vitamin d3 without improvement.this patient manifested an unusal form of hypophosphatemic rickets with hypercalciuria. it is recommended that urinary calcium excretion be assessed in all patients with hypophosphatemic rickets before the initiation of any therapy

Correspondence to: Dr Steven Ryan. Metabolic bone disease (MBD) in the newborn predominantly affects preterm neonates, although there are a few reports of babies with congenital rickets after maternal vitamin D deficiency. Features of MBD in preterm neonates include radiological abnormalities such as fractures, rickets, and osteoporosis; biochemical features such as raised blood alkaline phosph...