Corallopyronin A (CorA), a natural product antibiotic of Corallococcus coralloides , inhibits the bacterial DNA-dependent RNA polymerase. It is active against essential Wolbachia endobacteria filarial nematodes, preventing development, causing sterility and killing adult worms. CorA being developed to treat neglected tropical diseases onchocerciasis lymphatic filariasis caused by -containing fi...

We have cloned a DNA fragment from a genomic library of Myxococcus xanthus using an oligonucleotide probe representing conserved regions of biotin carboxylase subunits of acetyl coenzyme A (acetyl-CoA) carboxylases. The fragment contained two open reading frames (ORF1 and ORF2), designated the accB and accA genes, capable of encoding a 538-amino-acid protein of 58.1 kDa and a 573-amino-acid pro...

Myxobacteria are gram-negative, unicellular bacteria with rod-shaped vegetative cells. They are unique among prokaryotes for using intercellular communication to engage in cooperative morphogenesis from which they produce fruiting bodies bearing resistant myxospores (5). Thick-walled myxospores are responsible for the survival of myxobacteria under unfavorable conditions such as desiccation, hi...