Propofol is one of the main sedatives but its negative side effects limit its clinical application. Chitosan oligosaccharide (COS), a kind of natural product with anti-pain and anti-inflammatory activities, may be a potential adjuvant to propofol use. A total of 94 patients receiving surgeries were evenly and randomly assigned to two groups: 10 mg/kg COS oral administration and/or placebo oral ...

The generation of mature and vascularized human pluripotent stem cell-derived cardiac organoids (hPSC-COs) is necessary to ensure the validity drug screening disease modeling. This study investigates effects cellular aggregate (CA) stemness self-organization on hPSC-COs elucidates mechanisms underlying organoid (CO) maturation vascularization. COs derived from 2-day-old CAs with high (H-COs) 5-...

Dual-specificity thyrosine phosphorylation-regulated kinase 1A (DYRK1A) is a strong therapeutic target to ameliorate cognitive functions of Down Syndrome (DS). Genetic normalization of Dyrk1a is sufficient to normalize early cortical developmental phenotypes in DS mouse models. Gyrencephalic human neocortical development is more complex than that in lissencephalic mice; hence, cerebral organoid...

Aiming at the difficulty in real-time measuring and long offline measurement cycle for content of cement clinker free lime (fCaO), it is very important to build an online prediction model fCaO content. In this work, on basis Cholesky factorization, sequential multiple kernel extreme learning machine algorithm (COS-MKELM) proposed. The LDLT form factorization matrix introduced avoid large operat...

The C Object System (COS) is a small C library which implements high-level concepts available in CLOS, OBJECTIVEC and other object-oriented programming languages: uniform object model (class, metaclass and property-metaclass), generic functions, multi-methods, delegation, properties, exceptions, contracts and closures. COS relies on the programmable capabilities of the C programming language to...