Background & Objective: Busulfan (BUS) as a drug for cancer treatment can produce free radicals. Crocin (CRO) is a potent antioxidant with beneficial effects. This study was designed to evaluate the effects of CRO against BUS-related damages to the male rats reproductive parameters. Materials & Methods: Forty-eight male rats were randomly assigned into 8 groups; Group 1 (normal control group) ...

Streptococcus pneumoniaemajor cause of infection in children causes serious therapeutic difficulties, because of the developed multiresistance. Extended-spectrum cephalosporins, used in empirical therapy are a therapeutic option. Recent emergence of Ceftriaxone (CRO) and Cefotaxime (CTX) resistant strains with regional differences in frequency requires their detection by quantitative determinat...

A portion of the gene coding for the Cro repressor protein of bacteriophage X has been chemically synthesized, incorporating base pair changes that generate restriction endonuclease sites without altering the amino acid coding sequence. These restriction endonuclease sites were used to remove small segments of the synthetic cro gene and the segments were replaced with duplexes carrying desired ...

OBJECTIVE To assess clinical efficacy of controlled-release oxycodone (CRO) 20 mg on a 12-h dosing schedule in this prospective, randomised, placebo-controlled, double-blinded study of 40 ASA physical status I-III women undergoing breast surgery for cancer. RESEARCH DESIGN AND METHODS General anaesthesia using remifentanil and propofol was performed for surgery. Both groups received premedica...

The Reliability/Availability/Serviceability (RAS) strategy for S/390T G5 and G6 is to continue the S/390 objective of providing Continuous Reliable Operation (CRO). The RAS strategy is constructed with a set of building blocks which work closely together: error prevention, error detection, error recovery, problem determination, service structure, change management, and RAS measurement and analy...

The vibrational relaxation dynamics following the dissociation of CrO from M ( CO) 6 ( M = Cr, MO, W) have been studied with picosecond transient absorption spectroscopy. After dissociation of C=O, the pentacarbonyl species forms a complex with a solvent molecule. The cooling of these solvated pentacarbonyl complexes was monitored from 1 ps to 1 ns and different rates for vibrational relaxation...

Background and Purpose: The incidence of invasive fungal infections has been increased in recent years. The growing use of azole drugs for prophylactic and therapeutic purposes has resulted in the gradual emergence of azole-resistant species. Accordingly, the introduction of a new strategy to improve the management of Candida infections is an urgent need. Regarding this, the present study was p...

In this paper, an application of a novel chemical reaction optimization (CRO) algorithm for training higher order neural networks (HONNs), especially the Pi-Sigma Network (PSN) has been presented. In contrast to basic CRO algorithms, the proposed CRO algorithm used to train HONN possesses two modifications. The reactant size (population size) remains fixed throughout all the iteration, which ma...

The overall affinity of the bacteriophage lambda Cro repressor for its operator DNA site is limited by dimer dissociation at submicromolar concentrations. Since Cro dimer-operator complexes form at nanomolar concentrations of Cro subunits where free dimers are rare, these dimers must bind with compensating high affinities. Previous studies of the covalent dimer Cro V55C suggest little change in...