conclusions in this study¸ rosa damascena and mefenamic acid had similar effects on pain intensity of primary dysmenorrhea . with further studies, rosa damascena which has no chemical side effects¸ can be suggested for treating primary dysmenorrhea. results there was a significant difference between the average of pain intensity at different hours of measurement in each group after the end of f...

A randomized crossover trial of a new form of pediatric rehabilitation was conducted with 18 children with hemiparesis. Half were randomly assigned to receive pediatric constraint-induced therapy involving constraint of the functional upper extremity and intensive therapy with the hemiparetic upper extremity. Controls received conventional physical and occupational therapy and then were crossed...

In crossover trials, patients receive two or more treatments in a random order in different periods. The sample size determination is often an important step in planning a crossover study. This paper concerns sample size calculations in 2x2 crossover trials, with random patient effects and no interaction between the treatment and the patient under two scenarios, namely the exact and the large s...

OBJECTIVES To determine patient preferences and cost differences between home-based and hospital-based chemotherapy. DESIGN Randomised crossover trial. SETTING A tertiary cancer hospital in Melbourne, Victoria. PARTICIPANTS 20 patients who required chemotherapy suitable for administration at home. INTERVENTIONS Patients were assigned at random to receive their first chemotherapy treatme...

In the pharmacokinetic (PK) study under a 2x2 crossover design that involves both the test and reference drugs, we propose a mixed-effects model for the drug concentration-time profiles obtained from subjects who receive different drugs at different periods. In the proposed model, the drug concentrations repeatedly measured from the same subject at different time points are distributed accordin...

BACKGROUND Translating a question into a query using patient characteristics, type of intervention, control, and outcome (PICO) should help answer therapeutic questions in PubMed searches. The authors performed a randomized crossover trial to determine whether the PICO format was useful for quick searches of PubMed. METHODS Twenty-two residents and specialists working at the Radboud Universit...

BACKGROUND The cluster randomised crossover (CRXO) design is gaining popularity in trial settings where individual randomisation or parallel group cluster randomisation is not feasible or practical. Our aim is to stimulate discussion on the content of a reporting guideline for CRXO trials and to assess the reporting quality of published CRXO trials. METHODS We undertook a systematic review of...