Plasma fibronectin was determined in 121 normal adults and in 149 patients. Fibronectin levels in normals were strongly influenced by sex and age. The mean value of the protein in cancer patients did not differ from that in normal controls; however, patients with cryofibrinogenaemia or extensive liver metastases had lower values whereas those with obstructive jaundice due to pancreatic carcinom...

Cutaneous cryosurgery refers to localized application of freezing temperatures to achieve destruction of skin lesions. It can be used to treat a broad range of benign and premalignant skin conditions, and certain malignant skin conditions, with high cure rates. Cellular destruction is accomplished by delivery of the cryogen via dipstick, probe, or spray techniques. It is widely used in primary ...

PLASMA PROTEINS may be synthesized from amino acids derived directly from food, or may be constructed from other identical amino acids produced by the breakdown of intracellular proteins. In starvation or in malnutrition with a poor protein intake, the blood proteins are maintained to the last, in contrast to the organ proteins which may be utilized at the outset as a source of available amino ...

Henoch–Schö nlein purpura; IgA nephropathy; leuko-cytoclastic vasculitis; rapid progressive glomerulo-A 29-year-old patient sought medical advice in March nephritis; treatment 1998 for painful and swollen fingers. A week before hospital admission he had noticed progressive rash on the extremities, arthralgia of hips and shoulders and blue patches of skin on the dorsal fingers. He had a 10-year ...

BACKGROUND Cryofibrinogenaemia (CryoFg) is an under-recognized cryoprotein that can be life-threatening when untreated. Symptoms are mainly thrombotic cutaneous manifestations, but other thrombotic localizations may occur. In patients with end-stage renal disease, thromboses are common. However, the implication of CryoFg was never assessed. The aim of this study is to describe the prevalence an...

S everal recent reports,12 and one in this issue (see page 828), have contributed new observations on pulmonary disease in vinyl chloride (VC ) -and polyvinyl chloride (PVC) -exposed patients. Earlier reports, a few even preceding the identification in 1974 of vinyl chloride as a human carcinogen (with hemangiosarcoma of the liver the marker tumor, but most probably not the only tumor), had cen...