BACKGROUND Human epidermal growth factor receptor 2 (HER2) Ile655Val polymorphism may affect the efficacy of trastuzumab treatment of breast cancer. PATIENTS AND METHODS HER2 Ile655Val polymorphism was determined in 4167 patients with primary breast cancer using a polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) assay. We investigated the associations between the ...

BACKGROUND Certain somatic alterations in breast cancer can define prognosis and response to therapy. This study investigated the frequencies, prognostic effects, and predictive effects of known cancer somatic mutations using a randomized, adjuvant, phase III clinical trial dataset. METHODS The FinHER trial was a phase III, randomized adjuvant breast cancer trial involving 1010 women. Patient...

This paper presents a modified 32-bit ROM-based Direct Digital Frequency Synthesizer (DDFS). Maximum output frequency of the DDFS is limited by the structure of the accumulator used in the DDFS architecture. The hierarchical pipeline accumulator (HPA) presented in this paper has less propagation delay time rather than the conventional structures. Therefore, it results in both higher maximum ope...

Obesity is known to decrease the efficacy of neoadjuvant chemotherapy (NAC) against breast cancer; however, the relationship between actual body composition and NAC outcomes remains unknown. Therefore, we determined the effect of body composition on NAC outcomes. A total of 172 advanced breast cancer patients who underwent surgery after NAC were retrospectively analyzed. Body composition parame...

Coordinate rotation digital computer (CORDIC) is an efficient algorithm for computations of trigonometric functions. Scaling-free-CORDIC is one of the famous CORDIC implementations with advantages of speed and area. In this paper, a novel direct digital frequency synthesizer (DDFS) based on scaling-free CORDIC is presented. The proposed multiplier-less architecture with small ROM and pipeline d...

BACKGROUND As microRNAs (miRNA) may play important roles in tumorigenesis by regulating the expression of proto-oncogenes or tumor suppressor genes, the present study analyzed single nucleotide polymorphisms (SNPs) located in miRNA and miRNA-binding sites of various genes and their impact on prognosis for 452 patients with early breast cancer. MATERIALS AND METHODS Three SNPs of miR-196a (rs3...

BACKGROUND The impact of adjuvant chemotherapy on breast cancer prognosis has been demonstrated in randomized trials, but its impact is unknown in real-world populations. The aim of this study was to evaluate the effect of adjuvant chemotherapy on the survival of breast cancer patients in an unselected population. METHODS This prospective cohort study included 32,502 women treated at the Inst...

BACKGROUND To compare two types of therapy for primary breast carcinoma, breast-conserving therapy (BCT) and modified radical mastectomy (MRM), in a matched cohort study. METHODS A series of 1,746 patients with primary breast cancer treated with BCT or MRM in a single Chinese institute between January 2000 and February 2009 were analyzed retrospectively to compare their outcomes with respect ...

High-resolution low-power Direct Digital Frequency Synthesizers (DDFS) with small chip area are investigated. Lookup tables for sine and cosine yield the leading bits of the amplitudes. A CORDIC interpolation scheme enhances the amplitude precision. Systematic case studies using VHDL – models and synthesis indicate, that optimum LUT/CORDIC ratios can minimize use of power and silicon area. Intr...