a green and efficient one-pot, four-component synthesis of 6-amino-4-aryl-3-methyl-2,4-dihydropyrano[2,3- c ]pyrazo-carbonitrile derivatives catalyzed by borax in water is described. this method provides several advantages such as environmental friendliness, shorter reaction time, excellent yields, and simple workup procedure. the in vitro cytotoxic activity of the synthesized test compounds wa...

a mixture of acetaminophen, diphenhydramine hydrochloride and pseudoephedrine hydrochloride is used for the symptomatic treatment of common cold. in this study, a derivative spectrophotometric method based on zero-crossing technique was proposed for simultaneous determination of acetaminophen, diphenhydramine hydrochloride and pseudoephedrine hydrochloride. determination of these drugs was perf...

We develop a non-anticipative calculus for functionals of a continuous semimartingale, using an extension of the Ito formula to path-dependent functionals which possess certain directional derivatives. The construction is based on a pathwise derivative, introduced by B Dupire, for functionals on the space of right-continuous functions with left limits. We show that this functional derivative ad...

buprenorphine is a partial mu agonist and kappa antagonist which is used for the treatment of pain and opioid addiction. a mixture of buprenorphine hydrochloride and naloxone hydrochloride has been approved for the treatment of opioid dependence.in this study a third order derivative spectrophotometric method based on zero-crossing technique has been used for the simultaneous determination of b...

Starting from second-order conditions for C scalar unconstrained optimization problems described in terms of the second-order Dini directional derivative, we pose the problem, whether similar conditions for C vector optimization problems can be derived. We define second-order Dini directional derivatives for vector functions and apply them to formulate such conditions as a Conjecture. The proof...

A universal approach by Laplace transform to the variational iteration method for fractional derivatives with the nonsingular kernel is presented; in particular, the Caputo-Fabrizio fractional derivative and the Atangana-Baleanu fractional derivative with the non-singular kernel is considered. The analysis elaborated for both non-singular kernel derivatives is shown the necessity of considering...

The modification of the Clarke generalized subdiNerentia1 due to Michel and Penot is a useful tool in determining differentiability properties for certain classes of real functions on a normed linear space. The Glteaux differentiability of any real function can be deduced from the GBteaux differentiability of the norm if the function has a directional derivative which attains a constant related...

In this study, a derivative method is applied for the determination of dye concentration in fabrics dyed with tricomponent dye mixtures. The reflectance of spectra of the samples were recorded between 400 and 700 nm. Initially, the obtained (K/S) spectra were divided by the spectrum of a standard sample dyed with two of the components in the ternary mixture and the derivative spectra were calcu...

two sensitive spectrophotometric methods are presented for the assay of repaglinide in bulkdrug and in formulations using methyl orange, as reagents. oxidant by reacting with a fixedamount of either methyl orange and measuring the absorbance at 485.2 nm (method-i) andmeasuring the absorbance at 618.9 nm (method-ii). developed method is based on the formationof extractable colored complex of dru...