The aim of the present work was to develop immediate release dosage form of the solid dispersion of glimperide (GLIM) for potential enhancement in the bioavailability. The solid dispersions of GLIM were prepared with PEG6000, PVP K30 and Poloxamer 188, in 1:1, 1:3 and 1:5 %w/w ratio by using solvent wetting and solvent melt method. The in vitro dissolution parameters (%DE10min, %DE30min, %DE60m...

We provide error analyses for explicit, implicit, and semi-implicit monotone finitedifference schemes on uniform meshes with nonlocal numerical fluxes. We are motivated by finite-difference discretizations of certain long-wave (Sobolev) regularizations of the conservation laws that explicitly add a dispersive term as well as a nonlinear dissipative term. We also develop certain relationships be...

Lamotrigine is used in the treatment of CNS disorders, particularly epilepsy; pain; oedema; multiple sclerosis and psychiatric indications including bipolar disorder. Lamotrigine belongs to biopharmaceutical classification systems, BCS class II (Low solubility & High permeability). In addition, it requires immediate therapeutic action hence the main objective of this study is to improve the sol...

In the recent years, great interest has been devoted to the unique properties of nanofluids. The dispersion process and the nanoparticle suspension stability have been found to be critical points in the development of these new fluids. For this reason, an experimental study on the stability of water-based dispersions containing different nanoparticles, i.e. single wall carbon nanohorns (SWCNHs)...

Applicators have long recognized that temperature inversions dramatically influence the behavior of pesticide material released into the atmosphere during pesticide application. This behavior can be explained in terms of the relationship between vertical atmospheric temperature gradients (stability) and atmospheric mixing (turbulence). This relationship is not intuitively obvious, but once it i...

Weak, intermolecular interactions in amine dimers were studied by using the combination of a dispersionless density functional and a function that describes the dispersion contribution to the interaction energy. The validity of this method was shown by comparison of structural and energetic properties with data obtained with a conventional density functional and the coupled cluster method. The ...

The accelerating fields (e. g. centrifugal acceleration and constant acceleration) can change the physical performance of nano-sensors significantly. Herein, a new size-dependent model is developed to investigate the scale-dependent dynamic behavior of nanowire-fabricated sensor operated in an accelerating field. The scale-dependent equation of motion is developed by employing a consolidation o...

Thermodynamic stability of statistical systems requires that susceptibilities be semipositive and finite. Susceptibilities are known to be related to the fluctuations of extensive observable quantities. This relation becomes nontrivial, when the operator of an observable quantity is represented as a sum of operators corresponding to the extensive system parts. The association of the dispersions...

despite the great potential of graphene as a nanofiller, achieving homogeneous dispersion remains the key challenge for effectively reinforcing polyolefin (such as polyethylene (pe) and polypropylene (pp)) nanocomposites. therefore, in this research, we report a facile combined in situ polymerization and masterbatch method for fabricating pp/reduced graphene oxide (rgo) nanocomposites. in the p...