In rabbit livers, it is not well known which segments of the hepatic vasculature are predominantly contracted by various vasoconstrictors. We determined effects of histamine, norepinephrine, and KCl on hepatic vascular resistance distribution in isolated rabbit livers perfused via the portal vein with 5% albumin-Krebs solution at a constant flow rate. Hepatic capillary pressure was measured by ...

The quantitation of intracellular sodium ion concentration [Na+]in perfused organs using NMR spectroscopy requires a knowledge of the extent of visibility of the 23Na resonance and of the intracellular volume of the organ. We have used a multinuclear NMR approach, in combination with the extracellular shift reagent dysprosium (III) tripolyphosphate, to determine the NMR visibility of intra- and...

In decerebrated rats, we determined the pressor and cardioaccelerator reflex responses to static contraction of hindlimb muscles whose femoral arteries were either occluded 72 h before contraction, occluded 3 min before contraction, or freely perfused. We found that the pressor reflex arising from the limb whose femoral artery was occluded for 72 h before contraction (32 +/- 5 mmHg, n = 16) was...

This review is an attempt for a brief tracing of the main moments in the development of isolated perfused kidney method. It is emphasized the significance of this model and its application in various fields of science. The versatility of the isolated perfused kidney method is useful for modulating a number of pathophysiological processes, which could be helpful in studying and improving a bette...

Abstract Background Metoclopramide (MCP) is a dopamine D 2 ‐receptor antagonist, mainly used to treat post‐operative or chemotherapy‐induced nausea. While it very effective in the cure of gastric symptoms, MCP can cause severe neurologic side effects. Furthermore, there growing evidence for arrhythmic effects resulting from inhibitory on cardiac sodium and potassium channels. Methods Results Th...

We present an integrated experimental-computational mechanobiology model of chondrogenesis. The response of human articular chondrocytes to culture medium perfusion, versus perfusion associated with cyclic pressurisation, versus non-perfused culture, was compared in a pellet culture model, and multiphysic computation was used to quantify oxygen transport and flow dynamics in the various culture...