Mycobacterium tuberculosis strains that are resistant to an elevating number of second-line medicines used treat multidrug-resistant becoming a threat public health worldwide. Recent guidelines recommended at least 20 months treatment, but recent regimens toxic, poorly tolerated and insufficiently effective, with cure rates as low 36% failure high 50%. The emergence can be defined isoniazid rif...

multidrug-resistant (mdr) and extensively drug-resistant (xdr) tuberculosis (tb) are increasing globally. treatment options for these patients are very limited. although treatment of these patients with standardized regimen is associated with high mortality and morbidity, rational usage of new drugs might be promising. in this study we will review epidemiology of xdr-tb and tdr-tb in iran and t...

drug resistance (especially multiple drug resistance) in mycobacterium tuberculosis makes global concerns in treatment and control of tuberculosis. rapid diagnosis of drug resistant strains of the bacteria has vital importance in the prognosis of the disease. the aim of this study was to identify the mutations responsible for drug resistance in mycobacterium tuberculosis strains derived from pa...

background there is limited data on outcomes of adolescents with drug-resistant tuberculosis (dr-tb). objectives to describe patient outcomes and factors associated with outcomes of adolescents diagnosed with dr-tb in khayelitsha, south africa. patients and methods a retrospective analysis of data for adolescents aged 10-19 years who were diagnosed with dr-tb between january 2008 and august 201...

silicosis is considered to be among the occupational lung diseases and associated with sandblasting, mining, quarrying and tunneling. acute silicosis is usually progressive diseaseand despite treatment with corticosteroids it leads to cardio-respiratory failure and death. alveolar silicoproteinosis is one of it’s acute presentations due to exposure to silica dust and lungs filling with proteina...

background methicillin-resistant staphylococcus aureus (mrsa) remains a significant public health problem and treatment challenge. objectives this study was conducted to determine the frequency, molecular types, and drug resistance of s. aureus isolated from nasal carriers in two teaching hospitals (hajar and kashani) in shahrekord, southwestern iran. methods in this cross-sectional study, 262 ...

patients and methods two-hundred and fifty-five clinical specimens were collected from four major provinces of iran. samples were cultured and the mrsa strains were subjected to polymerase chain reaction (pcr). the patterns of antibiotic resistance were determined using the disk diffusion method. results seventy-four out of 255 (29.01%) clinical samples were positive for mrsa. of the 74 mrsa st...

conclusions pmf-dependent efflux mechanism appears to play an important role in the mdr phenotype of a. baumannii clinical strains. background multidrug-resistant (mdr) strains of acinetobacter baumannii have been increasingly reported as a major cause of nosocomial infections, and have created major therapeutic problems worldwide. objectives the aim of the present study was to evaluate the rol...

tuberculosis is a serious global public health problem and its high prevalence is stron gly associated with the enhancement of drug resistance. in this study we demonstrate a multiplex allele-specific polymerase chain reaction (mas)-pcr assay to simultaneously detect mutations in the first and third bases of the embb gene codon 306 atg in ethambutol (emb) resistant isolates of mycobacterium tub...

Drug resistance (especially multiple drug resistance) in Mycobacterium tuberculosis makes global concerns in treatment and control of tuberculosis. Rapid diagnosis of drug resistant strains of the bacteria has vital importance in the prognosis of the disease. The aim of this study was to identify the mutations responsible for drug resistance in Mycobacterium tuberculosis strains derived from pa...