INTRODUCTION New approaches for assessing disease progression in spinal muscular atrophy (SMA) are needed. In this study, we evaluate whether electrical impedance myography (EIM) can detect disease progression in SMA compared with a group of healthy children of similar age. METHODS Twenty-eight children with SMA and 20 normal children underwent repeated EIM testing in four muscles at regular ...

This study investigates the impact of the subcutaneous fat layer (SFL) thickness on localized electrical impedance myography (EIM), as well as the effects of different current electrodes, varying in distance and direction, on EIM output. Twenty-three healthy subjects underwent localized multi-frequency EIM on their biceps brachii muscles with a hand-held electrode array. The EIM measurements we...

OBJECTIVE To compare electrical impedance myography (EIM) 50 kHz phase to weight, motor score, paw grip endurance (PGE), CMAP amplitude, and MUNE for the identification of disease progression and the effect of riluzole in the SOD1 G93A mouse. METHODS Twenty-three animals received 8 mg/kg/day riluzole in the drinking water starting at 6 weeks of age; 22 animals served as controls. Weight, moto...

OBJECTIVES Methods are needed for quantifying muscle deconditioning due to immobilization, aging, or spaceflight. Electrical impedance myography (EIM) is one technique that may offer easy-to-follow metrics. Here, we evaluate the time course and character of the change in single- and multi-frequency EIM parameters in the hind-limb suspension model of muscle deconditioning in rats. METHODS Sixt...

The assumption that local baroclinic instability dominates eddy–mean flow interactions is tested on a global scale using a dynamically consistent eddy-permitting state estimate. Interactions are divided into local and nonlocal. If all the energy released from themean flow through eddy–mean flow interaction is used to support eddy growth in the same region, or if all the energy released from edd...

The assumption that local baroclinic instability dominates eddy–mean flow interactions is tested on a global scale using a dynamically consistent eddy-permitting state estimate. Interactions are divided into local and nonlocal. If all the energy released from themean flow through eddy–mean flow interaction is used to support eddy growth in the same region, or if all the energy released from edd...

The concept of Design-Build-Operate Energy Information Modeling (DBO-EIM) is proposed. The DBO-EIM aims at creating a detailed and persistent energy model that can be used to reduce energy consumption and improveoccupant comfort throughout the life-cycle of a building. Within the framework, the model is builtto supportdecision makingin the design phase, validated and tuned during construction a...

BACKGROUND AND AIMS Crohn's disease (CD) is commonly associated with inflammatory processes located in organs and systems others than the gut, which are known as extraintestinal manifestations (EIM) of the disease. The aim of this study was to assess the effectiveness of adalimumab (ADA) for the treatment of EIM in patients with CD. METHODS forty two consecutive CD patients with at least one ...

A global ocean circulation model is formulated in terms of the “residual mean” and used to study eddy–mean flow interaction. Adjoint techniques are used to compute the three-dimensional eddy stress field that minimizes the departure of the coarse-resolution model from climatological observations of temperature. The resulting 3D maps of eddy stress and residual-mean circulation yield a wealth of...