BACKGROUND AND PURPOSE Preclinical evidence indicates that iron plays a key role in mediating neuronal injury and edema formation after intracerebral hemorrhage (ICH). However, the clinical role of iron in patients with ICH has not been well studied. We undertook this exploratory study to investigate the association of serum ferritin, as an indicator of body iron load, with perihematoma edema a...

BCNU wafers are a form of interstitial chemotherapy that is expected to improve the survival of patients with malignant glioma. However, their adverse events, especially brain edema, sometimes cause significant clinical symptoms. In this study, we performed a volumetric analysis of brain edema after the implantation of BCNU wafers and reported on the clinical course, and exacerbation factors of...

BACKGROUND AND PURPOSE Blood-brain barrier permeability is not routinely evaluated in the clinical setting. Global cerebral edema occurs after SAH and is associated with BBB disruption. Detection of global cerebral edema using current imaging techniques is challenging. Our purpose was to apply blood-brain barrier permeability imaging in patients with global cerebral edema by using extended CT p...

Background: Curcumin is yellow pigment of tumeric, and, that is extracted from it lawsonia (2-hydroxy 1,4 naphtoquinon) is a natural product and it is extracted from henna. Ginger is a dried rhizomes gained from a plant called zingiber officinalea, which is extracted from the family of ginger. Material and Methods: This experimental study performed on adult male rats. Acute inflammatory edema ...

BACKGROUND AND PURPOSE Little is known about the relationship between perihematomal edema in spontaneous intracerebral hemorrhage (ICH) and outcome. The purpose of this study was to determine whether absolute or relative edema volume (edema volume divided by hematoma volume) predicts mortality or functional outcome in patients with hyperacute spontaneous ICH. We hypothesized that increasing bas...

In addition to local causes--for example, leak of dialysate into an inguinal hernia sac or into the anterior abdominal wall through the track of the catheter for continuous peritoneal dialysis (CPD)--scrotal edema in CPD patients may result from generalized volume retention. We present 2 CPD patients with scrotal edema, illustrating the diagnosis and management of the mechanisms of volume reten...

Hypertonic solutions play an important role in the treatment of tissue edema. Following the induction of experimental vasogenic brain edema by occlusion of the common carotid arteries in eight rabbits, the effect of hypertonic lactated Ringer's solution (subjects), vs. isotonic lactated Ringer's solution (control), was studied on blood pressure, electrolyte (sodium, potassium, and calcium) ...

In a past study of hyperoxia-induced lung injury, extensive lymphatic filling occurred that could have resulted from lymphatic proliferation or simple lymphatic recruitment. This study sought to determine if brief lung injury could produce similar changes, to show which lymphatic compartments fill with edema, and to compare their three-dimensional structure. Tracheostomized rats were ventilated...

BACKGROUND AND PURPOSE The mechanisms of perihematomal injury in primary intracerebral hemorrhage (ICH) are incompletely understood. An MRI study was designed to elucidate the nature of edema and blood flow changes after ICH. METHODS Perihematomal blood flow and edema were studied prospectively with perfusion-weighted MRI (PWI) and diffusion-weighted MRI in 21 ICH patients. MRI and computed t...