BACKGROUND Cadmium is a potent neurotoxic heavy metal, which induces oxidative stress and membrane disturbances in brain. Melatonin is an effective antioxidant and free radical scavenger against oxidative stress. The present study was designed to investigate the neuroprotective efficacy of melatonin in protecting the Cd induced changes in the activity of acetylcholinesterase (AChE), levels of l...

In vitro maturation (IVM) is emerging as a popular technology at the forefront of fertility treatment and preservation. However, standard in vitro culture conditions usually increase reactive oxygen species (ROS), which have been implicated as one of the major causes for reduced embryonic developmental competence. It is well-known that higher than physiological levels of ROS triggers granulosa ...

Oxidative stress occurs when the body’s enzymatic or non-enzymatic antioxidants are outweighed by endogenous exogenous free radicals. radicals, reactive oxygen species, and other biomolecule-damaging radicals can be generated during normal cellular metabolism react with proteins, lipids, DNA. In domains of biology medicine, have become increasingly important. They accumulate in a variety ways, ...

Plants are exposed to different ecological stress during their life cycle, and because of these tensions, free radicals shaped. Reactive oxygen species(ROS) have a fundamental ability support typical plant improvement tolerance. The disruption the proportionality ROS generation antioxidant defense systems is one primary effects biotic abiotic stress, resulting in an excess buildup oxidative dam...

Oxidative stress induced by alloxan is implicated in eliciting pathological changes in diabetes mellitus. This study was undertaken to determine the effect of P. edulis aqueous leaf extract on oral administration at a concentration of 200 mg/kg body weight for 30 days to alloxan treated animals. Liver and kidney were excised and used for biochemical studies like invitro lipid peroxidation, enzy...

Oral administration of 25 and 50 mg of aflatoxin in 0.2 mL olive oil/animal/day for 30 days caused dose-dependent and significantly higher lipid peroxidation in the kidney of aflatoxin-treated mice than in the controls. The levels of non-enzymatic antioxidant such as glutathione as well as the enzymatic antioxidants such as superoxide dismutase, glutathione peroxidase and catalase were signific...